Targeting mTOR for cancer therapy

H Hua, Q Kong, H Zhang, J Wang, T Luo… - Journal of hematology & …, 2019 - Springer
Mechanistic target of rapamycin (mTOR) is a protein kinase regulating cell growth, survival,
metabolism, and immunity. mTOR is usually assembled into several complexes such as …

Clinical delivery of circular RNA: lessons learned from RNA drug development

TL Young, KC Wang, AJ Varley, B Li - Advanced drug delivery reviews, 2023 - Elsevier
Circular RNAs (circRNA) represent a distinct class of covalently closed-loop RNA molecules,
which play diverse roles in regulating biological processes and disease states. The …

[HTML][HTML] Circ-ZNF609 is a circular RNA that can be translated and functions in myogenesis

I Legnini, G Di Timoteo, F Rossi, M Morlando, F Briganti… - Molecular cell, 2017 - cell.com
Circular RNAs (circRNAs) constitute a family of transcripts with unique structures and still
largely unknown functions. Their biogenesis, which proceeds via a back-splicing reaction, is …

Molecular Events Linking Oxidative Stress and Inflammation to Insulin Resistance and β‐Cell Dysfunction

KN Keane, VF Cruzat, R Carlessi… - Oxidative medicine …, 2015 - Wiley Online Library
The prevalence of diabetes mellitus (DM) is increasing worldwide, a consequence of the
alarming rise in obesity and metabolic syndrome (MetS). Oxidative stress and inflammation …

The new function of circRNA: translation

Y Shi, X Jia, J Xu - Clinical and Translational Oncology, 2020 - Springer
Circular RNAs (circRNAs) have been considered a special class of non-coding RNAs
without 5′ caps and 3′ tails which are covalently closed RNA molecules generated by …

RNA modifications and structures cooperate to guide RNA–protein interactions

CJT Lewis, T Pan, A Kalsotra - Nature reviews Molecular cell biology, 2017 - nature.com
An emerging body of evidence indicates that post-transcriptional gene regulation relies not
only on the sequence of mRNAs but also on their folding into intricate secondary structures …

Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?

W Filipowicz, SN Bhattacharyya… - Nature reviews …, 2008 - nature.com
MicroRNAs constitute a large family of small, approximately 21-nucleotide-long, non-coding
RNAs that have emerged as key post-transcriptional regulators of gene expression in …

Expanding uncapped translation and emerging function of circular RNA in carcinomas and noncarcinomas

Y Wang, C Wu, Y Du, Z Li, M Li, P Hou, Z Shen, S Chu… - Molecular cancer, 2022 - Springer
Circular RNAs (circRNAs) are classified as noncoding RNAs because they are devoid of a
5'end cap and a 3'end poly (A) tail necessary for cap-dependent translation. However …

Translational control in stress and apoptosis

M Holcik, N Sonenberg - Nature reviews Molecular cell biology, 2005 - nature.com
Cells respond to stress stimuli through coordinated changes in gene expression. The
regulation of translation is often used under these circumstances because it allows …

A review of the mammalian unfolded protein response

A Chakrabarti, AW Chen… - Biotechnology and …, 2011 - Wiley Online Library
Proteins requiring post‐translational modifications such as N‐linked glycosylation are
processed in the endoplasmic reticulum (ER). A diverse array of cellular stresses can lead to …