Ebselen, an organoselenium compound, mimics glutathione peroxidase activity. It is a
multifunctional compound, which catalyzes several essential reactions for the protection of …

Background Ebselen, an organoselenium compound and a clinically safe molecule has
been reported to possess potent antifungal activity, but its antifungal mechanism of action …

Bacterial multiresistance to drugs is a rapidly growing global phenomenon. New resistance
mechanisms have been described in different bacterial pathogens, threatening the effective …

Ebselen is a synthetic, lipid-soluble seleno-organic compound. The high electrophilicity of
ebselen enables it to react with multiple cysteine residues of various proteins. Despite …

The reaction of KSeOtBu with 2-iodo-arylbenzamides gave benzamide ring-substituted,
quinine-derived isoselenazolones 1b–1d. The reaction of PhSH with ortho-methyl …

Despite numerous studies on ebselen over the past decade, its cellular targets remain
obscure. Here we synthesized a biotinylated ebselen probe (biotin-ebselen) and …

Systemic infections by Candida spp. are associated with high mortality rates, partly due to
limitations in current antifungals, highlighting the need for novel drugs and drug targets. The …

Ebselen, a reactive organoselenium compound, was shown to inhibit toxins TcdA and TcdB
by covalently binding to their cysteine protease domains. It was suggested that ebselen …

Ebselen (EBS), 2-phenyl-1, 2-benzisoselenazol-3 (2 H)-one, is an organoselenium
pharmaceutical with antioxidant and anti-inflammatory properties. Furthermore, EBS is an …