Challenges and advances in clinical applications of mesenchymal stromal cells

T Zhou, Z Yuan, J Weng, D Pei, X Du, C He… - Journal of hematology & …, 2021 - Springer
Mesenchymal stromal cells (MSCs), also known as mesenchymal stem cells, have been
intensely investigated for clinical applications within the last decades. However, the majority …

A brief overview of global trends in MSC-based cell therapy

D Jovic, Y Yu, D Wang, K Wang, H Li, F Xu… - Stem cell reviews and …, 2022 - Springer
Human mesenchymal stem cells (MSCs), also known as mesenchymal stromal cells or
medicinal signaling cells, are important adult stem cells for regenerative medicine, largely …

Mesenchymal stromal cell therapies: immunomodulatory properties and clinical progress

X Wu, J Jiang, Z Gu, J Zhang, Y Chen, X Liu - Stem cell research & …, 2020 - Springer
Mesenchymal stromal cells (MSCs) are a subset of heterogeneous non-hematopoietic
fibroblast-like cells that can differentiate into cells of multiple lineages, such as …

Umbilical cord mesenchymal stromal cells as critical COVID-19 adjuvant therapy: a randomized controlled trial

IH Dilogo, D Aditianingsih, A Sugiarto… - Stem cells …, 2021 - academic.oup.com
One of the main causes of acute respiratory distress syndrome in coronavirus disease 2019
(COVID-19) is cytokine storm, although the exact cause is still unknown. Umbilical cord …

Improved MSC minimal criteria to maximize patient safety: a call to embrace tissue factor and hemocompatibility assessment of MSC products

G Moll, JA Ankrum, SD Olson… - Stem cells translational …, 2022 - academic.oup.com
The number of mesenchymal stromal/stem cell (MSC) therapeutics and types of clinical
applications have greatly diversified during the past decade, including rapid growth of poorly …

Impact of cryopreservation and freeze-thawing on therapeutic properties of mesenchymal stromal/stem cells and other common cellular therapeutics

C Cottle, AP Porter, A Lipat, C Turner-Lyles… - Current stem cell …, 2022 - Springer
Abstract Purpose of Review Cryopreservation and its associated freezing and thawing
procedures–short “freeze-thawing”–are among the final steps in economically viable …

The therapeutic potential of mesenchymal stromal cells for regenerative medicine: current knowledge and future understandings

M Merimi, R El-Majzoub, L Lagneaux… - Frontiers in Cell and …, 2021 - frontiersin.org
In recent decades, research on the therapeutic potential of progenitor cells has advanced
considerably. Among progenitor cells, mesenchymal stromal cells (MSCs) have attracted …

Evaluation of the safety and efficacy of using human menstrual blood‐derived mesenchymal stromal cells in treating severe and critically ill COVID‐19 patients: an …

X Xu, W Jiang, L Chen, Z Xu, Q Zhang… - Clinical and …, 2021 - Wiley Online Library
Abstract The coronavirus disease 2019 (COVID‐19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS‐CoV‐2) was identified in December 2019 and has …

Mesenchymal stromal cells for enhancing hematopoietic engraftment and treatment of graft-versus-host disease, hemorrhages and acute respiratory distress …

O Ringdén, G Moll, B Gustafsson… - Frontiers in …, 2022 - frontiersin.org
Mesenchymal stromal cells (MSCs) possess profound immunomodulatory and regenerative
properties that are of clinical use in numerous clinical indications with unmet medical need …

[HTML][HTML] Adverse events, side effects and complications in mesenchymal stromal cell-based therapies

DS Baranovskii, ID Klabukov… - Stem Cell …, 2022 - ncbi.nlm.nih.gov
Numerous clinical studies have shown a wide clinical potential of mesenchymal stromal
cells (MSCs) application. However, recent experience has accumulated numerous reports of …