Nerve terminals are specific sites of action of a very large number of toxins produced by
many different organisms. The mechanism of action of three groups of presynaptic …

Neurons can sustain high rates of synaptic transmission without exhausting their supply of
synaptic vesicles. This property relies on a highly efficient local endocytic recycling of …

The establishment of neural circuitry requires vast numbers of synapses to be generated
during a specific window of brain development, but it is not known why the develo** …

Neurotransmitter-containing synaptic vesicles (SVs) form tight clusters at synapses. These
clusters act as a reservoir from which SVs are drawn for exocytosis during sustained activity …

Synaptic transmission is mediated by neurotransmitters that are stored in synaptic vesicles
and released by exocytosis upon activation. The vesicle membrane is then retrieved by …

Most neurons form synapses exclusively with other neurons, but little is known about the
molecular mechanisms mediating synaptogenesis in the central nervous system. Using an …

Dynamic change of mitochondrial morphology and distribution along neuronal branches are
essential for neural circuitry formation and synaptic efficacy. However, the underlying …

Little is known about presynaptic assembly during central nervous system synaptogenesis.
Here we used time-lapse fluorescence imaging, immunocytochemistry and electron …

The architecture of the actin cytoskeleton that concentrates at presynapses remains poorly
known, hindering our understanding of its roles in synaptic physiology. In this work, we …

Time-lapse microscopy, retrospective immunohistochemistry, and cultured hippocampal
neurons were used to determine the time frame of individual glutamatergic synapse …