Antibacterial resistance is one of the greatest threats to human health. The development of
new therapeutics against bacterial pathogens has slowed drastically since the approvals of …

An ever-increasing demand for novel antimicrobials to treat life-threatening infections
caused by the global spread of multidrug-resistant bacterial pathogens stands in stark …

The reconstruction of bacterial and archaeal genomes from shotgun metagenomes has
enabled insights into the ecology and evolution of environmental and host-associated …

Soil harbors a vast expanse of unidentified microbes, termed as microbial dark matter,
presenting an untapped reservoir of microbial biodiversity and genetic resources, but has …

Natural microbial communities are phylogenetically and metabolically diverse. In addition to
underexplored organismal groups, this diversity encompasses a rich discovery potential for …

Background The relationship between biodiversity and soil microbiome stability remains
poorly understood. Here, we investigated the impacts of bacterial phylogenetic diversity on …

We are experiencing an antimicrobial resistance (AMR) crisis, brought on by the drying up of
the antibiotic discovery pipeline and the resulting unchecked spread of resistant pathogens …

Antibiotics and antibiotic resistance genes (ARGs) are prevalent in estuarine and coastal
environments due to substantial terrestrial input, aquaculture effluent, and sewage …

Fueled by the explosion of (meta) genomic data, genome mining of specialized metabolites
has become a major technology for drug discovery and studying microbiome ecology. In …

All organisms produce specialized organic molecules, ranging from small volatile chemicals
to large gene-encoded peptides, that have evolved to provide them with diverse cellular and …