Applications, challenges, and needs for employing synthetic biology beyond the lab

SM Brooks, HS Alper - Nature Communications, 2021 - nature.com
Synthetic biology holds great promise for addressing global needs. However, most current
developments are not immediately translatable to 'outside-the-lab'scenarios that differ from …

Applications of synthetic biology in medical and pharmaceutical fields

X Yan, X Liu, C Zhao, GQ Chen - Signal transduction and targeted …, 2023 - nature.com
Synthetic biology aims to design or assemble existing bioparts or bio-components for useful
bioproperties. During the past decades, progresses have been made to build delicate …

Progress in biopharmaceutical development

M Kesik‐Brodacka - Biotechnology and applied biochemistry, 2018 - Wiley Online Library
Since its introduction in 1982, biopharmaceutical drugs have revolutionized the treatment of
a broad spectrum of diseases and are increasingly used in nearly all branches of medicine …

Exploring the potential of cell-free protein synthesis for extending the abilities of biological systems

K Khambhati, G Bhattacharjee, N Gohil… - … in bioengineering and …, 2019 - frontiersin.org
Cell-free protein synthesis (CFPS) system is a simple, rapid, and sensitive tool that is devoid
of membrane-bound barriers, yet contains all the mandatory substrates, biomolecules, and …

Synthetic biology and metabolic engineering of actinomycetes for natural product discovery

E Palazzotto, Y Tong, SY Lee, T Weber - Biotechnology Advances, 2019 - Elsevier
Actinomycetes are one of the most valuable sources of natural products with industrial and
medicinal importance. After more than half a century of exploitation, it has become …

Synthetic biology goes cell-free

A Tinafar, K Jaenes, K Pardee - BMC biology, 2019 - Springer
Cell-free systems (CFS) have recently evolved into key platforms for synthetic biology
applications. Many synthetic biology tools have traditionally relied on cell-based systems …

Cell-free protein synthesis: a promising option for future drug development

SK Dondapati, M Stech, A Zemella, S Kubick - BioDrugs, 2020 - Springer
Proteins are the main source of drug targets and some of them possess therapeutic potential
themselves. Among them, membrane proteins constitute approximately 50% of the major …

Programming mammalian cell behaviors by physical cues

J Huang, M Fussenegger - Trends in Biotechnology, 2024 - cell.com
In recent decades, the field of synthetic biology has witnessed remarkable progress, driving
advances in both research and practical applications. One pivotal area of development …

Compartmentalizing cell-free systems: toward creating life-like artificial cells and beyond

E Cho, Y Lu - ACS Synthetic Biology, 2020 - ACS Publications
Building an artificial cell is a research area that is rigorously studied in the field of synthetic
biology. It has brought about much attention with the aim of ultimately constructing a natural …

Protein mediated enzyme immobilization

AA Caparco, DR Dautel, JA Champion - Small, 2022 - Wiley Online Library
Enzyme immobilization is an essential technology for commercializing biocatalysis. It
imparts stability, recoverability, and other valuable features that improve the effectiveness of …