One of the most prominent features of tumor cells is uncontrolled cell proliferation caused by
an abnormal cell cycle, and the abnormal expression of cell cycle-related proteins gives …

Colorectal cancer (CRC) is one of the most common malignancies with high prevalence and
low 5-year survival. CRC is a heterogeneous disease with a complex, genetic and …

Most of the current methods for programmable RNA drug therapies are unsuitable for the
clinic due to low uptake efficiency and high cytotoxicity. Extracellular vesicles (EVs) could …

Abstract N 6-methyladenosine (m6A) has been identified as the most abundant internal
modification of messenger RNA in eukaryotes. m6A modification is involved in cell fate …

In recent years, the highly conserved Lin28 RNA-binding proteins have emerged as factors
that define stemness in several tissue lineages. Lin28 proteins repress let-7 microRNAs and …

In recent years, microRNAs (miRNAs) have been identified as mediators of tumour
suppression and stress responses exerted by the p53 tumour suppressor. p53-regulated …

Sporadic Alzheimer's disease (AD) is the most prevalent form of dementia, but no clear
disease‐initiating mechanism is known. Aβ deposits and neuronal tangles composed of …

Multi-pathway approaches for the treatment of complex polygenic disorders are emerging as
alternatives to classical monotarget therapies and microRNAs are of particular interest in …

Background Cancer is one of the leading causes of mortality. The neoplastic transformation
of normal cells to cancer cells is caused by a progressive accumulation of genetic and …

The heterogeneous nature of acute myeloid leukemia (AML) and its poor prognosis
necessitate therapeutic improvement. Current advances in AML research yield important …