Evolution of leptin structure and function

RJ Denver, RM Bonett, GC Boorse - Neuroendocrinology, 2011 - karger.com
Leptin, the protein product of the obese (ob or Lep) gene, is a hormone synthesized by
adipocytes that signals available energy reserves to the brain, and thereby influences …

[HTML][HTML] Mechanisms regulating feed intake, energy expenditure, and body weight in poultry

MP Richards, M Proszkowiec-Weglarz - Poultry science, 2007 - Elsevier
To achieve energy balance and maintain a constant BW, changes in feed intake and energy
expenditure must be coordinated and tightly regulated. This may not hold true for some …

Two divergent leptin paralogues in zebrafish (Danio rerio) that originate early in teleostean evolution

M Gorissen, NJ Bernier, SB Nabuurs… - Journal of …, 2009 - joe.bioscientifica.com
The production of peptide hormones by skeletal muscle tissue is a promising area of gene
therapy. Skeletal muscle myogenesis can be induced in vitro, resulting in the fusion of …

Leptin as immune mediator: Interaction between neuroendocrine and immune system

C Procaccini, C La Rocca, F Carbone… - Developmental & …, 2017 - Elsevier
Leptin is an adipocyte-derived hormone/cytokine that links nutritional status with
neuroendocrine and immune functions. Initially described as an anti-obesity hormone, leptin …

Leptin and leptin receptor genes in Atlantic salmon: cloning, phylogeny, tissue distribution and expression correlated to long-term feeding status

I Rønnestad, TO Nilsen, K Murashita, AR Angotzi… - General and …, 2010 - Elsevier
The present study reports the complete coding sequences for two paralogues for leptin
(sLepA1 and sLepA2) and leptin receptor (sLepR) in Atlantic salmon. The deduced 171 …

Identification of the Long-Sought Leptin in Chicken and Duck: Expression Pattern of the Highly GC-Rich Avian leptin Fits an Autocrine/Paracrine Rather Than …

E Seroussi, Y Cinnamon, S Yosefi, O Genin… - …, 2016 - academic.oup.com
More than 20 years after characterization of the key regulator of mammalian energy balance,
leptin, we identified the leptin (LEP) genes of chicken (Gallus gallus) and duck (Anas …

Leptin neuroprotection in the CNS: mechanisms and therapeutic potentials

AP Signore, F Zhang, Z Weng, YQ Gao… - Journal of …, 2008 - Wiley Online Library
Leptin is well known as a hormone important in the central control of appetitive behaviors via
receptor‐mediated actions in the hypothalamus, where leptin adjusts food intake to maintain …

Assessing the functional role of leptin in energy homeostasis and the stress response in vertebrates

CA Deck, JL Honeycutt, E Cheung… - Frontiers in …, 2017 - frontiersin.org
Leptin is a pleiotropic hormone that plays a critical role in regulating appetite, energy
metabolism, growth, stress, and immune function across vertebrate groups. In mammals, it …

Leptin (ob gene) of the South African clawed frog Xenopus laevis

EJ Crespi, RJ Denver - Proceedings of the National Academy of Sciences, 2006 - pnas.org
Leptin, the protein product of the obese (ob) gene, is a type-I cytokine hormone secreted by
fat that is integral to food intake regulation and influences almost every physiological system …

Genomic characterization of multiple leptin genes and a leptin receptor gene in the Japanese medaka, Oryzias latipes

T Kurokawa, K Murashita - General and comparative endocrinology, 2009 - Elsevier
We comprehensively surveyed leptin (LEP) and leptin receptor (LEPR) genes in medaka,
Oryzias latipes and identified two LEP (mLEP-A and mLEP-B) genes and one LEPR …