Ante mortem diagnosis of tuberculosis in cattle: a review of the tuberculin tests, γ-interferon assay and other ancillary diagnostic techniques

R De la Rua-Domenech, AT Goodchild… - Research in veterinary …, 2006 - Elsevier
The early, preclinical stages of bovine TB can be detected in live animals by the use of tests
of cellular immunity (the skin, γ-interferon and lymphocyte transformation tests). Tests of …

Bovine tuberculosis: a review of current and emerging diagnostic techniques in view of their relevance for disease control and eradication

I Schiller, B Oesch, HM Vordermeier… - Transboundary and …, 2010 - Wiley Online Library
Existing strategies for long‐term bovine tuberculosis (bTB) control/eradication campaigns
are being reconsidered in many countries because of the development of new testing …

Diagnosis of Mycobacterium bovis infection in cattle by use of the gamma-interferon (Bovigam®) assay

E Gormley, MB Doyle, T Fitzsimons, K McGill… - Veterinary …, 2006 - Elsevier
The strategic use of the gamma-interferon (IFN-γ) assay (Bovigam®) can provide a means
for the early identification of Mycobacterium bovis infected cattle, thus ensuring their removal …

The History of In Vivo Tuberculin Testing in Bovines: Tuberculosis, a “One Health” Issue

M Good, D Bakker, A Duignan… - Frontiers in Veterinary …, 2018 - frontiersin.org
Tuberculosis (TB) is more than 3 million years old thriving in multiple species. Ancestral
Mycobacterium tuberculosis gave rise to multiple strains including Mycobacterium bovis now …

Using latent class analysis to estimate the test characteristics of the γ-interferon test, the single intradermal comparative tuberculin test and a multiplex immunoassay …

TA Clegg, A Duignan, C Whelan, E Gormley… - Veterinary …, 2011 - Elsevier
Considerable effort has been devoted to improving the existing diagnostic tests for bovine
tuberculosis (single intradermal comparative tuberculin test [SICTT] and γ-interferon assay [γ …

Multiplex Immunoassay for Serological Diagnosis of Mycobacterium bovis Infection in Cattle

C Whelan, E Shuralev, G O'Keeffe… - Clinical and Vaccine …, 2008 - journals.asm.org
Efforts to develop a better diagnostic assay for bovine tuberculosis have shown that the
sensitivity and specificity of an assay can be improved by the use of two or more antigens …

Repeat tuberculin skin testing leads to desensitisation in naturally infected tuberculous cattle which is associated with elevated interleukin-10 and decreased …

M Coad, D Clifford, SG Rhodes… - Veterinary …, 2009 - pmc.ncbi.nlm.nih.gov
The principal surveillance tool used to control bovine tuberculosis in cattle is the removal of
animals that provide a positive response to the tuberculin skin-test. In this study we …

Advances in bovine tuberculosis diagnosis and pathogenesis: what policy makers need to know

MV Palmer, WR Waters - Veterinary microbiology, 2006 - Elsevier
The mainstay of tuberculosis diagnosis in cattle and deer has been the tuberculin skin test.
Recent advances have allowed the incorporation of blood based assays to the diagnostic …

Bovine tuberculosis: effect of the tuberculin skin test on in vitro interferon gamma responses

I Schiller, HM Vordermeier, WR Waters… - Veterinary immunology …, 2010 - Elsevier
Bovine tuberculosis (bTB) is a disease of zoonotic and economic importance. In many
countries, control is based on test and slaughter policies and/or abattoir surveillance. For …