Macroautophagy and microautophagy are highly conserved eukaryotic cellular processes
that degrade cytoplasmic material in lysosomes. Both pathways involve characteristic …

Autophagy is a degradative pathway for cytoplasmic constituents, and is conserved across
eukaryotes. Autophagy-related (ATG) genes have undergone extensive multiplications and …

The endoplasmic reticulum (ER) is a central hub for the biogenesis of various organelles
and lipid‐containing structures. Recent studies suggest that vacuole membrane protein 1 …

Repeat proteins are common in all domains of life and exhibit a wide range of functions. One
class of repeat protein contains solenoid folds where the repeating unit consists of β-strands …

Solute carrier (SLC) proteins represent the largest superfamily of transmembrane
transporters. While many of them play key biological roles, their systematic analysis has …

Intracellular compartmentalization is a hallmark of eukaryotic cells. Dynamic membrane
remodeling, involving membrane fission/fusion events, clearly is crucial for cell viability and …

Autophagy is an intracellular degradation system involving de novo generation of
autophagosomes, which function as a transporting vesicle of cytoplasmic components to …

ABSTRACT TMEM41B and VMP1 are endoplasmic reticulum (ER)-localizing multi-spanning
membrane proteins required for ER-related cellular processes such as autophagosome …

The maintenance of a diverse and non-homogeneous lipid composition in cell membranes
is crucial for a multitude of cellular processes. One important example is transbilayer lipid …

Transmembrane proteins are active in amphipathic environments. To stabilize the protein in
such surrounding the exposure of hydrophobic residues on the protein surface is required …