Advances in multidisciplinary therapy for meningiomas

PK Brastianos, E Galanis, N Butowski, JW Chan… - Neuro …, 2019 - academic.oup.com
Surgery has long been established as the first-line treatment for the majority of symptomatic
and enlarging meningiomas, and evidence for its success is derived from retrospective case …

Radiotherapy for meningiomas

WC Chen, HK Perlow, A Choudhury, MP Nguyen… - Journal of neuro …, 2022 - Springer
Meningiomas are the most common primary central nervous system neoplasm. Despite
promising recent progress in elucidating the genomic landscape and underlying biology of …

Spatial genomic, biochemical and cellular mechanisms underlying meningioma heterogeneity and evolution

CHG Lucas, K Mirchia, K Seo, H Najem, WC Chen… - Nature …, 2024 - nature.com
Intratumor heterogeneity underlies cancer evolution and treatment resistance, but targetable
mechanisms driving intratumor heterogeneity are poorly understood. Meningiomas are the …

An artificial intelligence framework integrating longitudinal electronic health records with real-world data enables continuous pan-cancer prognostication

O Morin, M Vallières, S Braunstein, JB Ginart… - Nature Cancer, 2021 - nature.com
Despite widespread adoption of electronic health records (EHRs), most hospitals are not
ready to implement data science research in the clinical pipelines. Here, we develop …

Relationship between tumor location, size, and WHO grade in meningioma

ST Magill, JS Young, R Chae, MK Aghi… - Neurosurgical …, 2018 - thejns.org
OBJECTIVE Prior studies have investigated preoperative risk factors for meningioma;
however, no association has been shown between meningioma tumor size and tumor …

Targeted gene expression profiling predicts meningioma outcomes and radiotherapy responses

WC Chen, A Choudhury, MW Youngblood… - Nature medicine, 2023 - nature.com
Surgery is the mainstay of treatment for meningioma, the most common primary intracranial
tumor, but improvements in meningioma risk stratification are needed and indications for …

Integrated models incorporating radiologic and radiomic features predict meningioma grade, local failure, and overall survival

O Morin, WC Chen, F Nassiri, M Susko… - Neuro-oncology …, 2019 - academic.oup.com
Background We investigated prognostic models based on clinical, radiologic, and radiomic
feature to preoperatively identify meningiomas at risk for poor outcomes. Methods …

WHO grade I meningioma recurrence: identifying high risk patients using histopathological features and the MIB-1 index

AF Haddad, JS Young, I Kanungo, S Sudhir… - Frontiers in …, 2020 - frontiersin.org
Objective: In this study, we identify clinical, radiographic, and histopathologic
prognosticators of overall, early, and post-median recurrence in World Health Organization …

Intracranial meningiomas: an update of the 2021 World Health Organization classifications and review of management with a focus on radiation therapy

V Yarabarla, A Mylarapu, TJ Han, SL McGovern… - Frontiers in …, 2023 - frontiersin.org
Meningiomas account for approximately one third of all primary intracranial tumors. Arising
from the cells of the arachnoid mater, these neoplasms are found along meningeal surfaces …

Radiotherapy and radiosurgery for meningiomas

WC Chen, CHG Lucas, ST Magill… - Neuro-Oncology …, 2023 - academic.oup.com
Meningiomas comprise a histologically and clinically diverse set of tumors arising from the
meningothelial lining of the central nervous system. In the past decade, remarkable progress …