All soluble proteins populate conformational ensembles that together constitute the native
state. Their fluctuations in water are intrinsic thermodynamic phenomena, and the …

The GCN5-related N-acetyltransferases family (GNAT) is an important family of proteins that
includes more than 100000 members among eukaryotes and prokaryotes. Acetylation …

We isolated an 8 kDa mycobacterial hypothetical protein, Rv3423. 1, from the chromatin of
human macrophages infected with Mycobacterium tuberculosis H37Rv. Bioinformatics …

Ac (et) ylation is a post-translational modification present in all domains of life. First identified
in mammals in histones to regulate RNA synthesis, today it is known that is regulates …

Mycobacteria are endowed with rich and diverse machinery for the synthesis, utilization, and
degradation of cAMP. The actions of cyclic nucleotides are generally mediated by binding of …

Protein lysine acetylation is known to regulate multiple aspects of bacterial metabolism.
However, its presence in mycobacterial signal transduction and virulence-associated …

Arylalkylamine N-acyltransferases (AANATs) catalyze the formation of an N-acylamide from
an acyl-CoA thioester and an amine. One well known example is the production of N …

Listeria monocytogenes is a food and soil-borne pathogen that secretes a pore-forming toxin
listeriolysin O (LLO) as its major virulence factor. We tested the effects of LLO on an …

Two-component signal transduction (TCS) cascades involve stimulus-dependent activation
and phosphorylation of a sensor kinase (SK), which then transfers the phosphoryl moiety to …

Universal stress proteins (USPs) are present in many bacteria, and their expression is
enhanced under various environmental stresses. We have previously identified a USP in …