The balance between cell death and survival is a critical parameter in the regulation of cells
and the maintenance of homeostasis in vivo. Three major mechanisms for cell death have …

The serine/threonine kinase Akt is a master regulator of many diverse cellular functions,
including survival, growth, metabolism, migration, and differentiation. Receptor tyrosine …

Neuroinflammation and autophagy dysfunction are closely related to the development of
neurodegeneration such as Parkinson's disease (PD). However, the role of autophagy in …

Despite the immense importance of enzyme–substrate reactions, there is a lack of general
and unbiased tools for identifying and prioritizing substrate proteins that are modified by the …

Background Sepsis is a life-threatening organ dysfunction caused by an exaggerated
response to infection. In the lungs, one of the most susceptible organs, this can manifest as …

Simple Summary Breast cancer is the second leading cause of cancer-related death in
women in the United States. The Akt signaling pathway is deregulated in approximately 70 …

The serine threonine kinase AKT plays a central role in the regulation of cell survival in a
variety of human neoplastic diseases. A series of studies have revealed a connection …

Signaling pathways are responsible for transmitting information between cells and
regulating cell growth, differentiation, and death. Proteins in cells form complexes by …

Uptake of large volumes of extracellular fluid by actin-dependent macropinocytosis has an
important role in infection, immunity and cancer development. A key question is how actin …

The possibility of the pandemic spread of influenza viruses highlights the need for an
effective cure for this life-threatening disease. Influenza A virus, belonging to a family of …