Global Dissemination of Carbapenemase-Producing Klebsiella pneumoniae: Epidemiology, Genetic Context, Treatment Options, and Detection Methods

CR Lee, JH Lee, KS Park, YB Kim, BC Jeong… - Frontiers in …, 2016 - frontiersin.org
The emergence of carbapenem-resistant Gram-negative pathogens poses a serious threat
to public health worldwide. In particular, the increasing prevalence of carbapenem-resistant …

Carbapenemase-producing Klebsiella pneumoniae: molecular and genetic decoding

L Chen, B Mathema, KD Chavda, FR DeLeo… - Trends in …, 2014 - cell.com
Klebsiella pneumoniae carbapenemases (KPCs) were first identified in 1996 in the USA.
Since then, regional outbreaks of KPC-producing K. pneumoniae (KPC-Kp) have occurred …

Emergence of ST11-K47 and ST11-K64 hypervirulent carbapenem-resistant Klebsiella pneumoniae in bacterial liver abscesses from China: a molecular, biological …

Q Yang, X Jia, M Zhou, H Zhang, W Yang… - Emerging microbes & …, 2020 - Taylor & Francis
Background: Multidrug-resistant bacteria, especially those with high virulence, are an
emerging problem in clinical settings. Methods: We conducted a multicentre epidemiological …

Expansion of ESBL-producing Klebsiella pneumoniae in hospitalized patients: a successful story of international clones (ST15, ST147, ST336) and epidemic plasmids …

C Rodrigues, E Machado, H Ramos, L Peixe… - International Journal of …, 2014 - Elsevier
The aim of this study was to characterize by a multi-level approach extended-spectrum β-
lactamase (ESBL)-producing Enterobacteriaceae isolates other than E. coli from Portuguese …

Carbapenemase-producing Gram-negative bacteria: current epidemics, antimicrobial susceptibility and treatment options

SS Jean, WS Lee, C Lam, CW Hsu, RJ Chen… - Future …, 2015 - Taylor & Francis
Carbapenemases, with versatile hydrolytic capacity against β-lactams, are now an important
cause of resistance of Gram-negative bacteria. The genes encoding for the acquired …

First report of OXA-181-producing Escherichia coli in China and characterization of the isolate using whole-genome sequencing

Y Liu, Y Feng, W Wu, Y **e, X Wang… - Antimicrobial agents …, 2015 - Am Soc Microbiol
We report the first OXA-181-producing strain in China. bla OXA-181 was found in sequence
type 410 (ST410) Escherichia coli strain WCHEC14828 from a Chinese patient without …

Molecular and epidemiological characterization of carbapenemase-producing Enterobacteriaceae in Norway, 2007 to 2014

Ø Samuelsen, S Overballe-Petersen, JV Bjørnholt… - Plos one, 2017 - journals.plos.org
The prevalence of carbapenemase-producing Enterobacteriaceae (CPE) is increasing
worldwide. Here we present associated patient data and molecular, epidemiological and …

Horizontal transfer of carbapenemase-encoding plasmids and comparison with hospital epidemiology data

CA Hardiman, RA Weingarten, S Conlan… - Antimicrobial agents …, 2016 - Am Soc Microbiol
Carbapenemase-producing organisms have spread worldwide, and infections with these
bacteria cause significant morbidity. Horizontal transfer of plasmids carrying genes that …

Nationwide surveillance of antimicrobial resistance among clinically important Gram-negative bacteria, with an emphasis on carbapenems and colistin: Results from …

YL Lee, MC Lu, PL Shao, PL Lu, YH Chen… - International journal of …, 2019 - Elsevier
Multicentre surveillance of antimicrobial susceptibility of clinically important Gram-negative
bacteria (GNB) from 16 Taiwanese hospitals was performed. Escherichia coli (n= 398) …

Coexistence of a novel KPC-2-encoding MDR plasmid and an NDM-1-encoding pNDM-HN380-like plasmid in a clinical isolate of Citrobacter freundii

J Feng, Y Qiu, Z Yin, W Chen, H Yang… - Journal of …, 2015 - academic.oup.com
Objectives The objective of this study was to characterize the molecular mechanism of
coproduction of KPC-2 and NDM-1 in Citrobacter freundii. Methods C. freundii strain 112298 …