The striatum is essential for learning which actions lead to reward and for implementing
those actions. Decades of experimental and theoretical work have led to several influential …

The striatal and pallidal complexes are basal ganglia structures that orchestrate learning
and execution of flexible behavior. Models of how the basal ganglia subserve these …

Animals make predictions to guide their behavior and update those predictions through
experience. Transient increases in dopamine (DA) are thought to be critical signals for …

INTRODUCTION The drive to seek and experience reward is conserved across species and,
in mammals, involves interactions between subcortical dopaminergic systems and limbic …

The cortex projects to the dorsal striatum topographically, to regulate behaviour,–, but
spiking activity in the two structures has previously been reported to have markedly different …

A striking neurochemical form of compartmentalization has been found in the striatum of
humans and other species, dividing it into striosomes and matrix. The function of this …

Our original review,“Heterogeneity and Diversity of Striatal GABAergic Interneurons,” to
which this is an invited update, was published in December, 2010 in Frontiers is …

Beta oscillations in cortical-basal ganglia (BG) circuits have been implicated in normal
movement suppression and motor impairment in Parkinson's disease. To dissect the …

Historically, Parkinson's disease (PD) was defined as a pure movement disorder. Currently,
it is widely accepted that this disease is also characterized by nonmotor signs, such as …

The prevailing view is that striatal parvalbumin (PV)-positive interneurons primarily function
to downregulate medium spiny projection neuron (MSN) activity via monosynaptic inhibitory …