Membrane protrusions at the leading edge of cells, known as lamellipodia, drive cell
migration in many normal and pathological situations. Lamellipodial protrusion is powered …

Endocytosis occurs at the cell surface and involves internalization of the plasma membrane
(PM) along with its constituent membrane proteins and lipids. Endocytosis is involved in …

Peroxisomes have long been established to play a central role in regulating various
metabolic activities in mammalian cells. These organelles act in concert with mitochondria to …

We search in this paper for context-specific modes of three-dimensional (3D) cell migration
using imaging for phosphatidylinositol (3, 4, 5)-trisphosphate (PIP3) and active Rac1 and …

The Arp2/3 complex is an evolutionary conserved molecular machine that generates
branched actin networks. When activated, the Arp2/3 complex contributes the actin …

Lamellipodia, filopodia and membrane ruffles are essential for cell motility, the organization
of membrane domains, phagocytosis and the development of substrate adhesions. Their …

The Arp2/3 complex generates branched actin networks when activated by Nucleation
Promoting Factors (NPFs). Recently, the WASH family of NPFs has been identified, but its …

Summary Histone deacetylase 6 (HDAC6) is a tubulin-specific deacetylase that regulates
microtubule-dependent cell movement. In this study, we identify the F-actin-binding protein …

Cortactin fulfills many functions in various cell types. These functions have been considered
to derive from its ability to activate the Actin-related protein 2/3 (Arp2/3) complex, and are …

Actin polymerization often occurs at the plasma membrane to drive the protrusion of
lamellipodia and filopodia at the leading edge of migrating cells. A role for actin …