Inflammation, especially chronic inflammation, plays a pivotal role in tumorigenesis and
metastasis through various mechanisms and is now recognized as a hallmark of cancer and …

With a growing aged population, there is an imminent need to develop new therapeutic
strategies to ameliorate disorders of hematopoietic aging, including clonal hematopoiesis …

Despite genetic heterogeneity, myelodysplastic syndromes (MDSs) share features of
cytological dysplasia and ineffective hematopoiesis. We report that a hallmark of MDSs is …

Spliceosome mutations are common in myelodysplastic syndromes (MDS) and acute
myeloid leukaemia (AML), but the oncogenic changes due to these mutations have not been …

Background Myelodysplastic syndromes are a diverse and common group of chronic
hematologic cancers. The identification of new genetic lesions could facilitate new …

Chronic innate immune signaling in hematopoietic cells is widely described in
myelodysplastic syndromes (MDS), and innate immune pathway activation, predominantly …

X chromosome aneuploidies have long been associated with human cancers, but causality
has not been established. In mammals, X chromosome inactivation (XCI) is triggered by **st …

Despite evidence of chronic inflammation in myelodysplastic syndrome (MDS) and cell-
intrinsic dysregulation of Toll-like receptor (TLR) signaling in MDS hematopoietic stem and …

Recurring deletions of chromosome 7 and 7q [− 7/del (7q)] occur in myelodysplastic
syndromes and acute myeloid leukemia (AML) and are associated with poor prognosis …

Myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) are clonal
hematopoietic stem cell diseases arising from the bone marrow (BM), and approximately …