Dynamics and functions of lipid droplets
JA Olzmann, P Carvalho - Nature reviews Molecular cell biology, 2019 - nature.com
Lipid droplets are storage organelles at the centre of lipid and energy homeostasis. They
have a unique architecture consisting of a hydrophobic core of neutral lipids, which is …
have a unique architecture consisting of a hydrophobic core of neutral lipids, which is …
The functional universe of membrane contact sites
WA Prinz, A Toulmay, T Balla - Nature reviews Molecular cell biology, 2020 - nature.com
Organelles compartmentalize eukaryotic cells, enhancing their ability to respond to
environmental and developmental changes. One way in which organelles communicate and …
environmental and developmental changes. One way in which organelles communicate and …
Here, there, and everywhere: The importance of ER membrane contact sites
BACKGROUND The defining feature of eukaryotic cells is the presence of membrane-bound
organelles of diverse kinds, each with specialized functions. Most organelles have multiple …
organelles of diverse kinds, each with specialized functions. Most organelles have multiple …
Lipid droplets and liver disease: from basic biology to clinical implications
Lipid droplets are dynamic organelles that store neutral lipids during times of energy excess
and serve as an energy reservoir during deprivation. Many prevalent metabolic diseases …
and serve as an energy reservoir during deprivation. Many prevalent metabolic diseases …
Lipid droplet biogenesis
Lipid droplets (LDs) are ubiquitous organelles that store neutral lipids for energy or
membrane synthesis and act as hubs for metabolic processes. Cells generate LDs de novo …
membrane synthesis and act as hubs for metabolic processes. Cells generate LDs de novo …
The ménage à trois of autophagy, lipid droplets and liver disease
Y Filali-Mouncef, C Hunter, F Roccio, S Zagkou… - Autophagy, 2022 - Taylor & Francis
Autophagic pathways cross with lipid homeostasis and thus provide energy and essential
building blocks that are indispensable for liver functions. Energy deficiencies are …
building blocks that are indispensable for liver functions. Energy deficiencies are …
Lipid droplets and peroxisomes are co-regulated to drive lifespan extension in response to mono-unsaturated fatty acids
Dietary mono-unsaturated fatty acids (MUFAs) are linked to longevity in several species. But
the mechanisms by which MUFAs extend lifespan remain unclear. Here we show that an …
the mechanisms by which MUFAs extend lifespan remain unclear. Here we show that an …
DGAT1-dependent lipid droplet biogenesis protects mitochondrial function during starvation-induced autophagy
Lipid droplets (LDs) provide an" on-demand" source of fatty acids (FAs) that can be
mobilized in response to fluctuations in nutrient abundance. Surprisingly, the amount of LDs …
mobilized in response to fluctuations in nutrient abundance. Surprisingly, the amount of LDs …
Enzymatic noncovalent synthesis
Enzymatic reactions and noncovalent (ie, supramolecular) interactions are two fundamental
nongenetic attributes of life. Enzymatic noncovalent synthesis (ENS) refers to a process …
nongenetic attributes of life. Enzymatic noncovalent synthesis (ENS) refers to a process …
TMEM41B and VMP1 are scramblases and regulate the distribution of cholesterol and phosphatidylserine
TMEM41B and VMP1 are integral membrane proteins of the endoplasmic reticulum (ER)
and regulate the formation of autophagosomes, lipid droplets (LDs), and lipoproteins …
and regulate the formation of autophagosomes, lipid droplets (LDs), and lipoproteins …