Background: The Religious Orders Study and Rush Memory and Aging Project are both
ongoing longitudinal clinical-pathologic cohort studies of aging and Alzheimer's disease …

Functional Magnetic Resonance Imaging (fMRI) studies have become increasingly popular
both with clinicians and researchers as they are capable of providing unique insights into …

Growing evidence has shown that brain activity at rest slowly wanders through a repertoire
of different states, where whole-brain functional connectivity (FC) temporarily settles into …

Healthy aging has been associated with a decrease in functional network specialization.
Importantly, variability of alterations of functional connectivity is especially high across older …

This study tested the hypothesis that mid-life intellectual, physical, and social activities
contribute to cognitive reserve (CR). Two hundred five individuals (196 with magnetic …

Objective Cognitive reserve has been proposed to explain the discrepancy between clinical
symptoms and the effects of aging or Alzheimer's pathology. Functional magnetic resonance …

A growing body of evidence suggests that healthy elderly individuals and patients with
Alzheimer's disease retain an important potential for neuroplasticity. This review summarizes …

Alzheimer's disease (AD) is a progressive neurodegenerative disease, for which aging
remains the major risk factor. Aging is under a consistent pressure of increasing brain …

Background Fronto-striatal disconnection is thought to be at the basis of dysexecutive
symptoms in patients with Parkinson's disease (PD). Multiple reserve-related processes may …

The concept of cognitive reserve (CR) originated from discrepancies between the degree of
brain pathology and the severity of clinical manifestations. CR has been characterized …