Physiological roles of hydrogen sulfide in mammalian cells, tissues, and organs

G Cirino, C Szabo… - Physiological …, 2023 - journals.physiology.org
Over the last two decades, hydrogen sulfide (H2S) has emerged as an endogenous
regulator of a broad range of physiological functions. H2S belongs to the class of molecules …

A review of hydrogen sulfide synthesis, metabolism, and measurement: is modulation of hydrogen sulfide a novel therapeutic for cancer?

X Cao, L Ding, Z **e, Y Yang, M Whiteman… - Antioxidants & redox …, 2019 - liebertpub.com
Abstract Significance: Hydrogen sulfide (H2S) has been recognized as the third gaseous
transmitter alongside nitric oxide and carbon monoxide. In the past decade, numerous …

The first 1000 cultured species of the human gastrointestinal microbiota

M Rajilić-Stojanović, WM De Vos - FEMS microbiology reviews, 2014 - academic.oup.com
The microorganisms that inhabit the human gastrointestinal tract comprise a complex
ecosystem with functions that significantly contribute to our systemic metabolism and have …

Nutrients, foods, and colorectal cancer prevention

M Song, WS Garrett, AT Chan - Gastroenterology, 2015 - Elsevier
Diet has an important role in the development of colorectal cancer. In the past few decades,
findings from extensive epidemiologic and experimental investigations have linked …

Physiological implications of hydrogen sulfide: a whiff exploration that blossomed

R Wang - Physiological reviews, 2012 - journals.physiology.org
The important life-supporting role of hydrogen sulfide (H2S) has evolved from bacteria to
plants, invertebrates, vertebrates, and finally to mammals. Over the centuries, however, H2S …

Tumor-derived hydrogen sulfide, produced by cystathionine-β-synthase, stimulates bioenergetics, cell proliferation, and angiogenesis in colon cancer

C Szabo, C Coletta, C Chao, K Módis… - Proceedings of the …, 2013 - National Acad Sciences
The physiological functions of hydrogen sulfide (H2S) include vasorelaxation, stimulation of
cellular bioenergetics, and promotion of angiogenesis. Analysis of human colon cancer …

Relevance of protein fermentation to gut health

K Windey, V De Preter… - Molecular nutrition & food …, 2012 - Wiley Online Library
It is generally accepted that carbohydrate fermentation results in beneficial effects for the
host because of the generation of short chain fatty acids, whereas protein fermentation is …

Towards microbial fermentation metabolites as markers for health benefits of prebiotics

KA Verbeke, AR Boobis, A Chiodini… - Nutrition research …, 2015 - cambridge.org
Available evidence on the bioactive, nutritional and putative detrimental properties of gut
microbial metabolites has been evaluated to support a more integrated view of how …

Bile salt biotransformations by human intestinal bacteria

JM Ridlon, DJ Kang, PB Hylemon - Journal of lipid research, 2006 - ASBMB
Secondary bile acids, produced solely by intestinal bacteria, can accumulate to high levels
in the enterohepatic circulation of some individuals and may contribute to the pathogenesis …

Taurocholic acid metabolism by gut microbes and colon cancer

JM Ridlon, PG Wolf, HR Gaskins - Gut microbes, 2016 - Taylor & Francis
Colorectal cancer (CRC) is one of the most frequent causes of cancer death worldwide and
is associated with adoption of a diet high in animal protein and saturated fat. Saturated fat …