Dihydropyrimidines are the most important heterocyclic ring systems which play an
important role in the synthesis of DNA and RNA. Synthetically they were synthesized using …

Biginelli reaction involves acid-catalyzed one-pot synthesis of 3, 4-dihydropyrimidin-2 (1 H)-
ones (DHPMs) using easily-accessible starting materials, namely, aldehyde, active …

Introduction: The hybridization of biologically active molecules is a powerful tool for drug
discovery used to target a variety of diseases. It offers the prospect of better drugs for the …

Dihydropyrimidinones are heterocycles with a pyrimidine moiety in the ring nucleus, which,
in recent decades, have aroused interest in medicinal chemistry due to alleged versatile …

Cancer is a serious disease that has been around for a long time but currently has no
sustainable solution. Several medications currently available offer an opportunity for the …

Novel pyrimidinic selenoureas were synthesized and evaluated against tumour and normal
cell lines. Among these, the compound named 3j initially showed relevant cytotoxicity and …

A series of new hybrid fluorescent Biginelli compounds, including a Monastrol derivative,
were designed and synthesized with good yields. The photophysical studies revealed dual …

We report herein the synthesis of a new biologically active 3, 4-dihydropyrimidin-2 (1H)-
thione derivative (4) from 9-phenanthrenecarboxaldehyde, thiourea, and methyl …

Heterocyclic compounds have been featured as the key building blocks for the development
of biologically active molecules. In addition to being derived from renewable raw materials …

Abstract Dihydropyridines (DHPs) obtained from Hantzsch multicomponent reactions are an
important pharmaceutical class of compounds marketed as antihypertensive (eg, nifedipine …