The signal recognition particle (SRP) and its receptor compose a universally conserved and
essential cellular machinery that couples the synthesis of nascent proteins to their proper …

Ribosomes are universally conserved enzymes that carry out protein biosynthesis. Bacterial
and eukaryotic ribosomes, which share an evolutionarily conserved core, are thought to …

Ribosome stalling triggers quality control pathways targeting the mRNA (NGD: no‐go decay)
and the nascent polypeptide (RQC: ribosome‐associated quality control). RQC requires …

Macromolecular complexes are intrinsically flexible and often challenging to purify for
structure determination by single-particle cryo-electron microscopy (cryo-EM). Such …

Ribosomes translate genetic information encoded by messenger RNA into proteins. Many
aspects of translation and its regulation are specific to eukaryotes, whose ribosomes are …

Protein synthesis in all cells is carried out by macromolecular machines called ribosomes.
Although the structures of prokaryotic, yeast and protist ribosomes have been determined …

Historically, the ribosome has been viewed as a complex ribozyme with constitutive rather
than regulatory capacity in mRNA translation. Here we identify mutations of the Ribosomal …

Cotranslational protein translocation is a universally conserved process for secretory and
membrane protein biosynthesis. Nascent polypeptides emerging from a translating …

Structures of the bacterial ribosome have provided a framework for understanding universal
mechanisms of protein synthesis. However, the eukaryotic ribosome is much larger than it is …

A conserved heterotrimeric membrane protein complex, the Sec61 or SecY complex, forms a
protein-conducting channel, allowing polypeptides to be transferred across or integrated into …