The role of oxidative stress in cardiac disease: from physiological response to injury factor

R D'Oria, R Schipani, A Leonardini… - Oxidative medicine …, 2020 - Wiley Online Library
Reactive oxygen species (ROS) are highly reactive chemical species containing oxygen,
controlled by both enzymatic and nonenzymatic antioxidant defense systems. In the heart …

Evidence-based antenatal interventions to reduce the incidence of small vulnerable newborns and their associated poor outcomes

GJ Hofmeyr, RE Black, E Rogozińska, A Heuer… - The Lancet, 2023 - thelancet.com
A package of care for all pregnant women within eight scheduled antenatal care contacts is
recommended by WHO. Some interventions for reducing and managing the outcomes for …

[HTML][HTML] Effect of remote ischaemic conditioning on clinical outcomes in patients with acute myocardial infarction (CONDI-2/ERIC-PPCI): a single-blind randomised …

DJ Hausenloy, RK Kharbanda, UK Møller, M Ramlall… - The Lancet, 2019 - thelancet.com
Background Remote ischaemic conditioning with transient ischaemia and reperfusion
applied to the arm has been shown to reduce myocardial infarct size in patients with ST …

Remote ischemic preconditioning and outcomes of cardiac surgery

DJ Hausenloy, L Candilio, R Evans… - … England Journal of …, 2015 - Mass Medical Soc
Background Whether remote ischemic preconditioning (transient ischemia and reperfusion
of the arm) can improve clinical outcomes in patients undergoing coronary-artery bypass …

Ischaemic conditioning and reperfusion injury

DJ Hausenloy, DM Yellon - Nature Reviews Cardiology, 2016 - nature.com
The 30-year anniversary of the discovery of'ischaemic preconditioning'is in 2016. This
endogenous phenomenon can paradoxically protect the heart from acute myocardial …

Myocardial ischemia-reperfusion injury: a neglected therapeutic target

DJ Hausenloy, DM Yellon - The Journal of clinical investigation, 2013 - jci.org
Acute myocardial infarction (MI) is a major cause of death and disability worldwide. In
patients with MI, the treatment of choice for reducing acute myocardial ischemic injury and …

Novel targets and future strategies for acute cardioprotection: Position Paper of the European Society of Cardiology Working Group on Cellular Biology of the Heart

DJ Hausenloy, D Garcia-Dorado… - Cardiovascular …, 2017 - academic.oup.com
Ischaemic heart disease and the heart failure that often results, remain the leading causes of
death and disability in Europe and worldwide. As such, in order to prevent heart failure and …

Pathophysiology of acute kidney injury

DP Basile, MD Anderson… - Comprehensive …, 2012 - pmc.ncbi.nlm.nih.gov
Acute kidney injury (AKI) is the leading cause of nephrology consultation and is associated
with high mortality rates. The primary causes of AKI include ischemia, hypoxia or …

Interaction of risk factors, comorbidities, and comedications with ischemia/reperfusion injury and cardioprotection by preconditioning, postconditioning, and remote …

P Ferdinandy, DJ Hausenloy, G Heusch… - Pharmacological …, 2014 - Elsevier
Abstract Pre-, post-, and remote conditioning of the myocardium are well described adaptive
responses that markedly enhance the ability of the heart to withstand a prolonged …

The coronary circulation in acute myocardial ischaemia/reperfusion injury: a target for cardioprotection

DJ Hausenloy, W Chilian, F Crea… - Cardiovascular …, 2019 - academic.oup.com
The coronary circulation is both culprit and victim of acute myocardial infarction. The rupture
of an epicardial atherosclerotic plaque with superimposed thrombosis causes coronary …