NAD+/NADH and NADP+/NADPH in Cellular Functions and Cell Death: Regulation and Biological Consequences
W Ying - Antioxidants & redox signaling, 2008 - liebertpub.com
C. NADP synthesis D. Catabolism of NAD and NADP E. Relationships between NAD and
NADP F. NAD transport across mitochondrial membranes G. NAD transport across the …
NADP F. NAD transport across mitochondrial membranes G. NAD transport across the …
Inositol Trisphosphate Receptor Ca2+ Release Channels
The inositol 1, 4, 5-trisphosphate (InsP3) receptors (InsP3Rs) are a family of Ca2+ release
channels localized predominately in the endoplasmic reticulum of all cell types. They …
channels localized predominately in the endoplasmic reticulum of all cell types. They …
The diverse functions of GAPDH: views from different subcellular compartments
C Tristan, N Shahani, TW Sedlak, A Sawa - Cellular signalling, 2011 - Elsevier
Multiple roles for glyceraldehyde-3-phosphate dehydrogenase (GAPDH) have been recently
appreciated. In addition to the cytoplasm where the majority of GAPDH is located under the …
appreciated. In addition to the cytoplasm where the majority of GAPDH is located under the …
Metabolic dysregulation contributes to the progression of Alzheimer's disease
X Yan, Y Hu, B Wang, S Wang, X Zhang - Frontiers in neuroscience, 2020 - frontiersin.org
Alzheimer's disease (AD) is an incurable neurodegenerative disease. Numerous studies
have demonstrated a critical role for dysregulated glucose metabolism in its pathogenesis …
have demonstrated a critical role for dysregulated glucose metabolism in its pathogenesis …
VDAC1 at the intersection of cell metabolism, apoptosis, and diseases
V Shoshan-Barmatz, A Shteinfer-Kuzmine, A Verma - Biomolecules, 2020 - mdpi.com
The voltage-dependent anion channel 1 (VDAC1) protein, is an important regulator of
mitochondrial function, and serves as a mitochondrial gatekeeper, with responsibility for …
mitochondrial function, and serves as a mitochondrial gatekeeper, with responsibility for …
Redox regulation of cardiac calcium channels and transporters
AV Zima, LA Blatter - Cardiovascular research, 2006 - academic.oup.com
Intracellular concentrations of redox-active molecules can significantly increase in the heart
as a result of activation of specific signal transduction pathways or the development of …
as a result of activation of specific signal transduction pathways or the development of …
Glycolytic metabolism, brain resilience, and Alzheimer's disease
Alzheimer's disease (AD) is the most common form of age-related dementia. Despite
decades of research, the etiology and pathogenesis of AD are not well understood. Brain …
decades of research, the etiology and pathogenesis of AD are not well understood. Brain …
Thiol-based redox switches in eukaryotic proteins
N Brandes, S Schmitt, U Jakob - Antioxidants & redox signaling, 2009 - liebertpub.com
For many years, oxidative thiol modifications in cytosolic proteins were largely disregarded
as in vitro artifacts, and considered unlikely to play significant roles within the reducing …
as in vitro artifacts, and considered unlikely to play significant roles within the reducing …
GAPDH, a novel regulator of the pro-apoptotic mitochondrial membrane permeabilization
Abstract Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a pleiotropic enzyme that
is overexpressed in apoptosis and in several human chronic pathologies. Here, we report …
is overexpressed in apoptosis and in several human chronic pathologies. Here, we report …
Oxidatively modified glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and Alzheimer's disease: many pathways to neurodegeneration
DA Butterfield, SS Hardas… - Journal of Alzheimer's …, 2010 - content.iospress.com
Abstract Recently, the oxidoreductase, glyceraldehyde-3-phosphate dehydrogenase
(GAPDH), has become a subject of interest as more and more studies reveal a surfeit of …
(GAPDH), has become a subject of interest as more and more studies reveal a surfeit of …