Lights, fiber, action! A primer on in vivo fiber photometry

EH Simpson, T Akam, T Patriarchi, M Blanco-Pozo… - Neuron, 2024 - cell.com
Fiber photometry is a key technique for characterizing brain-behavior relationships in vivo.
Initially, it was primarily used to report calcium dynamics as a proxy for neural activity via …

Two-photon calcium imaging of neuronal activity

C Grienberger, A Giovannucci, W Zeiger… - Nature Reviews …, 2022 - nature.com
In vivo two-photon calcium imaging (2PCI) is a technique used for recording neuronal
activity in the intact brain. It is based on the principle that, when neurons fire action …

Fluorescent proteins and genetically encoded biosensors

M Wang, Y Da, Y Tian - Chemical Society Reviews, 2023 - pubs.rsc.org
The genetically encoded fluorescent sensors convert chemical and physical signals into
light. They are powerful tools for the visualisation of physiological processes in living cells …

Multifunctional materials for implantable and wearable photonic healthcare devices

GH Lee, H Moon, H Kim, GH Lee, W Kwon… - Nature Reviews …, 2020 - nature.com
Numerous light-based diagnostic and therapeutic devices are routinely used in the clinic.
These devices have a familiar look as items plugged in the wall or placed at patients' …

A positively tuned voltage indicator for extended electrical recordings in the brain

SW Evans, DQ Shi, M Chavarha, MH Plitt, J Taxidis… - Nature …, 2023 - nature.com
Genetically encoded voltage indicators (GEVIs) enable optical recording of electrical signals
in the brain, providing subthreshold sensitivity and temporal resolution not possible with …

Focused ultrasound excites cortical neurons via mechanosensitive calcium accumulation and ion channel amplification

S Yoo, DR Mittelstein, RC Hurt, J Lacroix… - Nature …, 2022 - nature.com
Ultrasonic neuromodulation has the unique potential to provide non-invasive control of
neural activity in deep brain regions with high spatial precision and without chemical or …

Genetically encoded fluorescent biosensors illuminate the spatiotemporal regulation of signaling networks

EC Greenwald, S Mehta, J Zhang - Chemical reviews, 2018 - ACS Publications
Cellular signaling networks are the foundation which determines the fate and function of
cells as they respond to various cues and stimuli. The discovery of fluorescent proteins over …

Dual-polarity voltage imaging of the concurrent dynamics of multiple neuron types

M Kannan, G Vasan, S Haziza, C Huang… - Science, 2022 - science.org
Genetically encoded fluorescent voltage indicators are ideally suited to reveal the
millisecond-scale interactions among and between targeted cell populations. However …

Bright and photostable chemigenetic indicators for extended in vivo voltage imaging

AS Abdelfattah, T Kawashima, A Singh, O Novak, H Liu… - Science, 2019 - science.org
Genetically encoded voltage indicators (GEVIs) enable monitoring of neuronal activity at
high spatial and temporal resolution. However, the utility of existing GEVIs has been limited …

[HTML][HTML] Ultrafast two-photon imaging of a high-gain voltage indicator in awake behaving mice

V Villette, M Chavarha, IK Dimov, J Bradley, L Pradhan… - Cell, 2019 - cell.com
Optical interrogation of voltage in deep brain locations with cellular resolution would be
immensely useful for understanding how neuronal circuits process information. Here, we …