Protein posttranslational modifications (PTMs) refer to the breaking or generation of covalent
bonds on the backbones or amino acid side chains of proteins and expand the diversity of …

Aging is a physiological process mediated by numerous biological and genetic pathways,
which are directly linked to lifespan and are a driving force for all age-related diseases …

About a year ago, members of the editorial board of Biogerontology were requested to
respond to a query by the editor-in-chief of the journal as to what one question within their …

Women are born with all of their oocytes. The oocyte proteome must be maintained with
minimal damage throughout the woman's reproductive life, and hence for decades. Here we …

Aging is characterized by a decline in tissue function, but the underlying changes at cellular
resolution across the organism remain unclear. Here, we present the Aging Fly Cell Atlas, a …

Ulcerative colitis (UC) is a chronic inflammatory disease of the intestine that presents
clinically with abdominal pain, mucopurulent stools, and posterior urgency. The lesions of …

Aging is a prominent risk factor for neurodegenerative disorders (NDDs); however, the
molecular mechanisms rendering the aged brain particularly susceptible to …

Aging is characterized by the accumulation of damage and other deleterious changes,
leading to the loss of functionality and fitness. Age-related changes occur at most levels of …

The biomechanical properties of extracellular matrices (ECM) and their consequences for
cellular homeostasis have recently emerged as a driver of aging. Here we review the age …

Ulcerative colitis (UC) is a clinically common, progressive, devastating, chronic inflammatory
disease of the intestine that is recurrent and difficult to treat. Nod-like receptor protein 3 …