The increasing life expectancy of humans has led to a growing numbers of patients with
chronic diseases and end-stage organ failure. Transplantation is an effective approach for …

Transplantation is often the last resort for end-stage organ failures, eg, kidney, liver, heart,
lung, and pancreas. The shortage of donor organs is the main limiting factor for successful …

For many patients with terminal/advanced cardiac failure, heart transplantation is the most
effective, durable treatment option, and offers the best prospects for a high quality of life. The …

Introduction There is a continuing worldwide shortage of organs from deceased human
donors for transplantation into patients with end-stage organ failure. Genetically engineered …

Chronic heart failure is the end stage of cardiac diseases. With a high prevalence and a high
mortality rate worldwide, chronic heart failure is one of the heaviest health-related burdens …

Half a million patients in the USA alone require treatment for burns annually. Following an
extensive burn, it may not be possible to provide sufficient autografts in a single setting. Pig …

Xenotransplantation: past, present, and future : Current Opinion in Organ Transplantation
Xenotransplantation: past, present, and future : Current Opinion in Organ Transplantation Log in …

Xenotransplantation has the potential to solve the shortfall of human organ donors.
Genetically modified pigs have been considered as potential animal donors for human …

End-stage organ failure can result from various preexisting conditions and occurs in patients
of all ages, and organ transplantation remains its only treatment. In recent years, extensive …

Progress in pig organ xenotransplantation has been made largely through (1) genetic
engineering of the organ-source pig to protect its tissues from the human innate immune …