Emerging applications of nanotechnology for controlling cell‐surface receptor clustering
The spatial organization of cell‐surface receptors plays an important role in defining cell
fate. Recently, the development of strategies for the direct regulation of receptor clustering …
fate. Recently, the development of strategies for the direct regulation of receptor clustering …
Ligand-independent receptor clustering modulates transmembrane signaling: a new paradigm
MF Sánchez, R Tampé - Trends in Biochemical Sciences, 2023 - cell.com
Cell-surface receptors mediate communication between cells and their environment. Lateral
membrane organization and dynamic receptor cluster formation are fundamental in signal …
membrane organization and dynamic receptor cluster formation are fundamental in signal …
In Situ DNA Self-Assembly on the Cell Surface Drives Unidirectional Clustering of Membrane Proteins for the Modulation of Cell Behaviors
Cell membrane proteins play a pivotal role in regulating intracellular signal transductions
and cell behaviors. Many membrane proteins form clusters in order to initiate downstream …
and cell behaviors. Many membrane proteins form clusters in order to initiate downstream …
[HTML][HTML] Controlled spatial characteristics of ligands on nanoparticles: determinant of cellular functions
Interactions of various ligands and receptors have been extensively investigated because
they regulate a series of signal transduction leading to various functional cellular outcomes …
they regulate a series of signal transduction leading to various functional cellular outcomes …
Membrane receptor activation mechanisms and transmembrane peptide tools to elucidate them
Single-pass membrane receptors contain extracellular domains that respond to external
stimuli and transmit information to intracellular domains through a single transmembrane …
stimuli and transmit information to intracellular domains through a single transmembrane …
Logic nanodevice-mediated receptor assembly for nongenetic regulation of cell behavior in tumor-like microenvironment
Y Wu, J Huang, H He, M Wang, G Yin, L Qi, X He… - Nano Letters, 2023 - ACS Publications
The reprogramming of cell signaling and behavior through the artificial control of cell surface
receptor oligomerization shows great promise in biomedical research and cell-based …
receptor oligomerization shows great promise in biomedical research and cell-based …
New perspectives on the roles of nanoscale surface topography in modulating intracellular signaling
The physical properties of biomaterials, such as elasticity, stiffness, and surface
nanotopography, are mechanical cues that regulate a broad spectrum of cell behaviors …
nanotopography, are mechanical cues that regulate a broad spectrum of cell behaviors …
Spatial organization-dependent EphA2 transcriptional responses revealed by ligand nanocalipers
T Verheyen, T Fang, D Lindenhofer… - Nucleic acids …, 2020 - academic.oup.com
Ligand binding induces extensive spatial reorganization and clustering of the EphA2
receptor at the cell membrane. It has previously been shown that the nanoscale spatial …
receptor at the cell membrane. It has previously been shown that the nanoscale spatial …
Using enhanced number and brightness to measure protein oligomerization dynamics in live cells
Protein dimerization and oligomerization are essential to most cellular functions, yet
measurement of the size of these oligomers in live cells, especially when their size changes …
measurement of the size of these oligomers in live cells, especially when their size changes …
Critical parameters for design and development of multivalent nanoconstructs: Recent trends
A century ago, the groundbreaking concept of the magic bullet was given by Paul Ehrlich.
Since then, this concept has been extensively explored in various forms to date. The concept …
Since then, this concept has been extensively explored in various forms to date. The concept …