Nanomaterials toward the treatment of Alzheimer's disease: Recent advances and future trends

H Zeng, Y Qi, Z Zhang, C Liu, W Peng, Y Zhang - Chinese chemical letters, 2021 - Elsevier
Alzheimer's disease (AD) is a progressive and fatal neurodegenerative condition and the
most prevalent cause of dementia. This disease is characterized by progressive cognitive …

Microglia and the blood–brain barrier: An external player in acute and chronic neuroinflammatory conditions

GS Gullotta, G Costantino, MA Sortino… - International Journal of …, 2023 - mdpi.com
Microglia are the resident immune cells of the central nervous system that guarantee
immune surveillance and exert also a modulating role on neuronal synaptic development …

Antioxidant activity of fluoxetine and vortioxetine in a non-transgenic animal model of alzheimer's disease

G Caruso, M Grasso, A Fidilio, SA Torrisi… - Frontiers in …, 2021 - frontiersin.org
Depression is a risk factor for the development of Alzheimer's disease (AD). A
neurobiological and clinical continuum exists between AD and depression, with …

Melittin and diclofenac synergistically promote wound healing in a pathway involving TGF-β1

BG Eid, NA Alhakamy, UA Fahmy, OAA Ahmed… - Pharmacological …, 2022 - Elsevier
A dysregulation of the wound healing process can lead to the development of various
intractable ulcers or excessive scar formation. Therefore it is essential to identify novel …

The therapeutic potential of carnosine as an antidote against drug-induced cardiotoxicity and neurotoxicity: Focus on nrf2 pathway

G Caruso, A Privitera, BM Antunes, G Lazzarino… - Molecules, 2022 - mdpi.com
Different drug classes such as antineoplastic drugs (anthracyclines, cyclophosphamide, 5-
fluorouracil, taxanes, tyrosine kinase inhibitors), antiretroviral drugs, antipsychotic, and …

Antioxidant properties of second-generation antipsychotics: Focus on microglia

G Caruso, M Grasso, A Fidilio, F Tascedda, F Drago… - Pharmaceuticals, 2020 - mdpi.com
Recent studies suggest a primary role of oxidative stress in an early phase of the
pathogenesis of schizophrenia and a strong neurobiological link has been found between …

Gap junctions and connexins in microglia-related oxidative stress and neuroinflammation: perspectives for drug discovery

G Caruso, L Di Pietro, F Caraci - Biomolecules, 2023 - mdpi.com
Microglia represent the immune system of the brain. Their role is central in two phenomena,
neuroinflammation and oxidative stress, which are at the roots of different pathologies …

The role of PI3K signaling pathway in Alzheimer's disease

J Pan, Q Yao, Y Wang, S Chang, C Li, Y Wu… - Frontiers in Aging …, 2024 - frontiersin.org
Alzheimer's disease (AD) is a debilitating progressively neurodegenerative disease. The
best-characterized hallmark of AD, which is marked by behavioral alterations and cognitive …

[HTML][HTML] The therapeutic potential of carnosine: Focus on cellular and molecular mechanisms

G Caruso, L Di Pietro, V Cardaci, S Maugeri… - Current Research in …, 2023 - Elsevier
Carnosine is a naturally occurring endogenous dipeptide composed by the ligation of β-
alanine and L-histidine performed particularly by tissues with an increased oxidative …

The therapeutic potential of novel carnosine formulations: perspectives for drug development

A Bonaccorso, A Privitera, M Grasso, S Salamone… - Pharmaceuticals, 2023 - mdpi.com
Carnosine (beta-alanyl-L-histidine) is an endogenous dipeptide synthesized via the activity
of the ATP-dependent enzyme carnosine synthetase 1 and can be found at a very high …