Psychedelics are quite unique among drugs that impact the central nervous system, as a
single administration of a psychedelic can both rapidly alter subjective experience in …

Abstract Background Rapid-acting antidepressants (RAADs), including dissociative
anesthetics, psychedelics, and empathogens, elicit rapid and sustained therapeutic …

Objective: The primary aim of this qualitative study was to delineate psychological
mechanisms of change in the first randomized controlled trial of psilocybin-assisted …

Alzheimer's Disease (AD) is a currently incurable but increasingly prevalent fatal and
progressive neurodegenerative disease, demanding consideration of therapeutically …

Mounting evidence points towards a crucial role of the kynurenine pathway (KP) in the
altered gut-brain axis (GBA) balance in severe mental illness (SMI, namely depression …

Background and Purpose Psychedelics elicit prosocial, antidepressant and anxiolytic effects
via neuroplasticity, neurotransmission and neuro‐immunomodulatory mechanisms. Whether …

Anxiety disorders (ADs) represent the sixth leading cause of disability worldwide, resulting in
a significant global economic burden. Over 50% of individuals with ADs do not respond to …

There has recently been a resurgence of interest in psychedelic compounds based on
studies demonstrating their potential therapeutic applications in treating post-traumatic …

Schizophrenia is a severe brain disorder that usually produces a lifetime of disability. First
generation or typical antipsychotics such as haloperidol and second generation or atypical …

Psychedelic compounds are being increasingly explored as a potential therapeutic option
for treating several psychiatric conditions, despite relatively little being known about their …