Fanconi anemia is a genetic disorder that is characterized by bone marrow failure, as well
as a predisposition to malignancies including leukemia and squamous cell carcinoma …

Cancer is a complex disease in which several molecular and cellular pathways converge to
foster the tumoral phenotype. Notably, in the latest iteration of the cancer hallmarks,“ …

Reactive aldehydes are potent genotoxins that threaten the integrity of hematopoietic stem
cells and blood production. To protect against aldehydes, mammals have evolved a family of …

Aged hematopoietic stem cells (HSCs) display diminished self-renewal and a myeloid
differentiation bias. However, the drivers and mechanisms that underpin this fundamental …

Long-read sequencing technologies have improved the contiguity and, as a result, the
quality of genome assemblies by generating reads long enough to span and resolve …

Accurate and complete genome duplication is crucial to maintain cell survival and prevent
malignant transformation. The Fanconi anemia (FA) pathway has traditionally been …

Reactive aldehydes, for instance, formaldehyde and acetaldehyde, are important
endogenous or environmental mutagens by virtue of their abilities to produce a DNA lesion …

Acute myeloid leukemia (AML) is an aggressive malignancy characterized by challenges in
treatment, including drug resistance and frequent relapse. Recent research highlights the …

We have identified a set of Japanese children with hypoplastic anemia caused by combined
defects in aldehyde degrading enzymes ADH5 and ALDH2. Their clinical characteristics …

As a leading cause of mortalities worldwide, cancer results from accumulation of both
genetic and epigenetic alterations. Disruption of epigenetic regulation in cancer, particularly …