Life cycle maintenance and drug-sensitivity assays for early drug discovery in Schistosoma mansoni

FC Lombardo, V Pasche, G Panic, Y Endriss… - Nature Protocols, 2019 - nature.com
Drug discovery for schistosomiasis is still limited to a handful of academic laboratories
worldwide, with only a few novel antischistosomal lead compounds being actively …

Integrated multi-omic analyses in Biomphalaria-Schistosoma dialogue reveal the immunobiological significance of FREP-SmPoMuc interaction

A Portet, S Pinaud, G Tetreau, R Galinier… - Developmental & …, 2017 - Elsevier
The fresh water snail Biomphalaria glabrata is one of the vectors of the trematode pathogen
Schistosoma mansoni, which is one of the agents responsible of human schistosomiasis. In …

[HTML][HTML] A quantitative proteomic analysis of the tegumental proteins from Schistosoma mansoni schistosomula reveals novel potential therapeutic targets

J Sotillo, M Pearson, L Becker, J Mulvenna… - International journal for …, 2015 - Elsevier
The tegument of Schistosoma mansoni plays an integral role in host–parasite interactions,
particularly during the transition from the free-living cercariae to the intra-mammalian …

Single-cell atlas of the first intra-mammalian developmental stage of the human parasite Schistosoma mansoni

CL Diaz Soria, J Lee, T Chong, A Coghlan… - Nature …, 2020 - nature.com
Over 250 million people suffer from schistosomiasis, a tropical disease caused by parasitic
flatworms known as schistosomes. Humans become infected by free-swimming, water-borne …

Protease inhibitors of parasitic flukes: emerging roles in parasite survival and immune defence

SL Ranasinghe, DP McManus - Trends in Parasitology, 2017 - cell.com
Protease inhibitors play crucial roles in parasite development and survival, counteracting the
potentially damaging immune responses of their vertebrate hosts. However, limited …

Stem cell heterogeneity drives the parasitic life cycle of Schistosoma mansoni

B Wang, J Lee, P Li, A Saberi, H Yang, C Liu, M Zhao… - Elife, 2018 - elifesciences.org
Schistosomes are parasitic flatworms infecting hundreds of millions of people. These
parasites alternate between asexual reproduction in molluscan hosts and sexual …

Whole genome resequencing of the human parasite Schistosoma mansoni reveals population history and effects of selection

T Crellen, F Allan, S David, C Durrant, T Huckvale… - Scientific reports, 2016 - nature.com
Schistosoma mansoni is a parasitic fluke that infects millions of people in the develo**
world. This study presents the first application of population genomics to S. mansoni based …

Functional expression of a novel Kunitz type protease inhibitor from the human blood fluke Schistosoma mansoni

SL Ranasinghe, K Fischer, GN Gobert, DP McManus - Parasites & Vectors, 2015 - Springer
Background Schistosomes are able to survive for prolonged periods in the blood system,
despite continuous contact with coagulatory factors and mediators of the host immune …

The esophageal gland mediates host immune evasion by the human parasite Schistosoma mansoni

J Lee, T Chong, PA Newmark - Proceedings of the National Academy of …, 2020 - pnas.org
Schistosomes are parasitic flatworms that cause schistosomiasis, a neglected tropical
disease affecting over 200 million people. Schistosomes develop multiple body plans while …

A gene expression atlas of adult Schistosoma mansoni and their gonads

Z Lu, F Sessler, N Holroyd, S Hahnel, T Quack… - Scientific data, 2017 - nature.com
RNA-Seq has proven excellence in providing information about the regulation and transcript
levels of genes. We used this method for profiling genes in the flatworm Schistosoma …