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Life cycle maintenance and drug-sensitivity assays for early drug discovery in Schistosoma mansoni
FC Lombardo, V Pasche, G Panic, Y Endriss… - Nature Protocols, 2019 - nature.com
Drug discovery for schistosomiasis is still limited to a handful of academic laboratories
worldwide, with only a few novel antischistosomal lead compounds being actively …
worldwide, with only a few novel antischistosomal lead compounds being actively …
Integrated multi-omic analyses in Biomphalaria-Schistosoma dialogue reveal the immunobiological significance of FREP-SmPoMuc interaction
The fresh water snail Biomphalaria glabrata is one of the vectors of the trematode pathogen
Schistosoma mansoni, which is one of the agents responsible of human schistosomiasis. In …
Schistosoma mansoni, which is one of the agents responsible of human schistosomiasis. In …
[HTML][HTML] A quantitative proteomic analysis of the tegumental proteins from Schistosoma mansoni schistosomula reveals novel potential therapeutic targets
The tegument of Schistosoma mansoni plays an integral role in host–parasite interactions,
particularly during the transition from the free-living cercariae to the intra-mammalian …
particularly during the transition from the free-living cercariae to the intra-mammalian …
Single-cell atlas of the first intra-mammalian developmental stage of the human parasite Schistosoma mansoni
Over 250 million people suffer from schistosomiasis, a tropical disease caused by parasitic
flatworms known as schistosomes. Humans become infected by free-swimming, water-borne …
flatworms known as schistosomes. Humans become infected by free-swimming, water-borne …
Protease inhibitors of parasitic flukes: emerging roles in parasite survival and immune defence
Protease inhibitors play crucial roles in parasite development and survival, counteracting the
potentially damaging immune responses of their vertebrate hosts. However, limited …
potentially damaging immune responses of their vertebrate hosts. However, limited …
Stem cell heterogeneity drives the parasitic life cycle of Schistosoma mansoni
Schistosomes are parasitic flatworms infecting hundreds of millions of people. These
parasites alternate between asexual reproduction in molluscan hosts and sexual …
parasites alternate between asexual reproduction in molluscan hosts and sexual …
Whole genome resequencing of the human parasite Schistosoma mansoni reveals population history and effects of selection
T Crellen, F Allan, S David, C Durrant, T Huckvale… - Scientific reports, 2016 - nature.com
Schistosoma mansoni is a parasitic fluke that infects millions of people in the develo**
world. This study presents the first application of population genomics to S. mansoni based …
world. This study presents the first application of population genomics to S. mansoni based …
Functional expression of a novel Kunitz type protease inhibitor from the human blood fluke Schistosoma mansoni
Background Schistosomes are able to survive for prolonged periods in the blood system,
despite continuous contact with coagulatory factors and mediators of the host immune …
despite continuous contact with coagulatory factors and mediators of the host immune …
The esophageal gland mediates host immune evasion by the human parasite Schistosoma mansoni
Schistosomes are parasitic flatworms that cause schistosomiasis, a neglected tropical
disease affecting over 200 million people. Schistosomes develop multiple body plans while …
disease affecting over 200 million people. Schistosomes develop multiple body plans while …
A gene expression atlas of adult Schistosoma mansoni and their gonads
Z Lu, F Sessler, N Holroyd, S Hahnel, T Quack… - Scientific data, 2017 - nature.com
RNA-Seq has proven excellence in providing information about the regulation and transcript
levels of genes. We used this method for profiling genes in the flatworm Schistosoma …
levels of genes. We used this method for profiling genes in the flatworm Schistosoma …