The protein kinase, GSK-3, participates in diverse biological processes and is now
recognized a promising drug discovery target in treating multiple pathological conditions …

The epigenetic clock is defined by the DNA methylation (DNAm) level and has been
extensively applied to distinguish biological age from chronological age. Aging-related …

Cilia defects lead to scoliosis in zebrafish, but the underlying pathogenic mechanisms are
poorly understood and may diverge depending on the mutated gene. Here, we dissected the …

CDKL5 deficiency disorder (CDD), a rare and severe neurodevelopmental disease caused
by mutations in the X-linked CDKL 5 gene, is characterized by early-onset epilepsy …

Abstract MECP2 duplication syndrome (MDS), a rare X‐linked genomic disorder affecting
predominantly males, is caused by duplication of the chromosomal region containing the …

Mutations in X-linked gene methyl-CpG-binding protein 2 (MECP2), a key transcriptional
regulator, account for most cases of Rett syndrome (RTT), a devastating …

Rett syndrome (RTT) is a progressive neurodevelopmental disorder mainly caused by
mutations in the X-linked MECP2 gene. RTT patients show multisystem disturbances …

To date, Rett syndrome (RTT), a genetic disorder mainly caused by mutations in the X-linked
MECP2 gene, is increasingly considered a broad-spectrum pathology, instead of just a …

Cyclin‐dependent kinase‐like 5 (CDKL5, also known as STK9) is a serine/threonine protein
kinase originally identified in 1998 during a transcriptional map** project of the human X …

Leptin inhibits food intake and reduces the size of body fat depots, changing adipocyte
sensitivity to insulin to restrain lipid accrual. This adipokine may modulate the production of …