Actions of symbiotic gut microbiota are in dynamic balance with the host's organism to
maintain homeostasis. Many different factors have an impact on this relationship, including …

In healthy individuals, metabolically quiescent T cells survey lymph nodes and peripheral
tissues in search of cognate antigens. During infection, T cells that encounter cognate …

Background Dysregulation of gut microbiota-associated tryptophan metabolism has been
observed in patients with multiple sclerosis. However, defining direct mechanistic links …

T cell subsets are critically involved in the development of systemic autoimmunity and organ
inflammation in systemic lupus erythematosus (SLE). Each T cell subset function (such as …

Multiple sclerosis (MS) is an inflammatory demyelinating disorder of the CNS. Bile acids are
cholesterol metabolites that can signal through receptors on cells throughout the body …

FOXP3+ Tregs rely on fatty acid β-oxidation–driven (FAO-driven) oxidative phosphorylation
(OXPHOS) for differentiation and function. Recent data demonstrate a role for Tregs in the …

The microbiome can be defined as the sum of the microbial and host's genome. Recent
information regarding this complex organ suggests that in animal models of multiple …

Metabolic aberrations impact the pathogenesis of multiple sclerosis (MS) and possibly can
provide clues for new treatment strategies. Using untargeted metabolomics, we measured …

The gut-brain axis is a bi-directional integrated system composed by immune, endocrine,
and neuronal components by which the gap between the gut microbiota and the brain is …

Cardiovascular diseases (CVDs) are the leading cause of premature morbidity and mortality
globally. The identification of novel risk factors contributing to CVD onset and progression …