Candida albicans is a major fungal pathogen of humans. It exists as a commensal in the oral
cavity, gut or genital tract of most individuals, constrained by the local microbiota, epithelial …

SUMMARY A significant increase in the incidence of Candida-mediated infections has been
observed in the last decade, mainly due to rising numbers of susceptible individuals …

The continuing emergence of invasive fungal pathogens poses an increasing threat to
public health. Here, through the China Hospital Invasive Fungal Surveillance Net …

Cells of the innate immune system, notably macrophages, neutrophils and dendritic cells,
perform essential antimicrobial and homeostatic functions. These functions rely on the …

The immune system has to cope with a wide range of irregularly shaped pathogens that can
actively move (eg, by flagella) and also dynamically remodel their shape (eg, transition from …

An important host defence mechanism against pathogens is intracellular killing, which is
achieved through phagocytosis, a cellular process for engulfing and neutralizing …

Patients with decreased levels of CD18 (β2 integrins) suffer from life-threatening bacterial
and fungal infections. CD11b, the α subunit of integrin CR3 (CD11b/CD18, αMβ2), is …

Innate immunity provides essential protection against life-threatening fungal infections.
However, the outcomes of individual skirmishes between immune cells and fungal …

Candida albicans is both a commensal and an opportunistic fungal pathogen. Invading
hyphae of C. albicans secrete candidalysin, a pore-forming peptide toxin. To prevent cell …

Phagocytosis is a dynamic process that requires an intricate interplay between phagocytic
receptors, membrane lipids, and numerous signalling proteins and their effectors, to …