The 5-Adenosine monophosphate (AMP)-activated protein kinase (AMPK) is a natural
energy sensor in mammalian cells that plays a key role in cellular and systemic energy …

The field of cAMP signaling is witnessing exciting developments with the recognition that
cAMP is compartmentalized and that spatial regulation of cAMP is critical for faithful signal …

Mitochondria are key organelles for cellular homeostasis. They generate the most part of
ATP that is used by cells through oxidative phosphorylation. They also produce reactive …

In the complex microcosm of a cell, information security and its faithful transmission are
critical for maintaining internal stability. To achieve a coordinated response of all its parts to …

Phosphorylation of mitochondrial proteins has emerged as a major regulatory mechanism
for metabolic adaptation. cAMP signaling and PKA phosphorylation of mitochondrial …

Abstract Cyclic adenosine 3, 5′-monophosphate (cAMP) is a ubiquitous second
messenger regulating many biological processes, such as cell migration, differentiation …

Rationale: Although the second messenger cyclic AMP (cAMP) is physiologically beneficial
in the heart, it largely contributes to cardiac disease progression when dysregulated. Current …

Under physiological conditions, cAMP signaling plays a key role in the regulation of cardiac
function. Activation of this intracellular signaling pathway mirrors cardiomyocyte adaptation …

The prototypical second messenger cAMP regulates a wide variety of physiological
processes. It can simultaneously mediate diverse functions by acting locally in …

Acid-base homeostasis is essential for life. The macromolecules upon which living
organisms depend are sensitive to pH changes, and physiological systems use the …