Dexmedetomidine is a potent alpha-2-adrenergic agonist, more selective than clonidine,
with widespread actions on the mammalian brain that include sedation, anaesthetic-sparing …

Dexmedetomidine (Precedex®), a pharmacologically active dextroisomer of medetomidine,
is a selective α 2-adrenergic receptor agonist. It is indicated in the US for the sedation of …

Cardiac dysfunction resulting from sepsis may cause significant morbidity and mortality, and
ferroptosis plays a role in this pathology. Dexmedetomidine (Dex), a α2-adrenergic receptor …

Abstract The SLC7A11/GPX4 axis plays an important role in ferroptosis during cardiac
ischemia/reperfusion injury (IRI). The present study was designed to evaluate the impact of …

Spinal cord injury (SCI) consists of a two-steps process involving a primary mechanical
injury followed by an inflammatory process and apoptosis. Secondary insult is characterized …

Dexmedetomidine, selective α2-adrenergic agonist dexmedetomidine, has been widely
used clinically for sedation and anesthesia. The role of dexmedetomidine has been an …

The α2 adrenergic receptors (α2ARs) are G protein-coupled receptors (GPCRs) that
respond to adrenaline and noradrenaline and couple to the Gi/o family of G proteins. α2ARs …

Background: Intestinal ischemia-reperfusion (I/R) injury is a devastating complication in the
perioperative period. Dexmedetomidine is commonly applied in the perioperative period …

The effects of dexmedetomidine in adults undergoing cardiac surgery are inconsistent. We
conducted a systematic review and meta‐analysis to analyse the effects of peri‐operative …

Dexmedetomidine (Dex) is a highly selective α2-adrenergic receptor agonist that is widely
used for sedation in intensive care units and in clinical anesthesia. Dex has also been …