A review of neutrophil extracellular traps (NETs) in disease: potential anti-NETs therapeutics
V Mutua, LJ Gershwin - Clinical reviews in allergy & immunology, 2021 - Springer
Activated neutrophils release neutrophil extracellular traps (NETs) in response to a variety of
stimuli. NETosis is driven by protein-arginine deiminase type 4, with the release of …
stimuli. NETosis is driven by protein-arginine deiminase type 4, with the release of …
Neutrophil intrinsic and extrinsic regulation of NETosis in health and disease
Neutrophil extracellular traps (NETs) evolved to protect the host against microbial infections
and are formed by a web-like structure of DNA that is decorated with antimicrobial effectors …
and are formed by a web-like structure of DNA that is decorated with antimicrobial effectors …
Phase 1 double-blind randomized safety trial of the Janus kinase inhibitor tofacitinib in systemic lupus erythematosus
Increased risk of premature cardiovascular disease (CVD) is well recognized in systemic
lupus erythematosus (SLE). Aberrant type I-Interferon (IFN)-neutrophil interactions contribute …
lupus erythematosus (SLE). Aberrant type I-Interferon (IFN)-neutrophil interactions contribute …
Neutrophil extracellular traps (NETs) take the central stage in driving autoimmune responses
Following fifteen years of research, neutrophil extracellular traps (NETs) are widely reported
in a large range of inflammatory infectious and non-infectious diseases. Cumulating …
in a large range of inflammatory infectious and non-infectious diseases. Cumulating …
Bite of the wolf: innate immune responses propagate autoimmunity in lupus
S Gupta, MJ Kaplan - The Journal of clinical investigation, 2021 - Am Soc Clin Investig
The etiopathogenesis of systemic lupus erythematosus (SLE), a clinically heterogeneous
multisystemic syndrome that derives its name from the initial characterization of facial …
multisystemic syndrome that derives its name from the initial characterization of facial …
Advances in the pathogenesis and treatment of systemic lupus erythematosus
Systemic lupus erythematosus (SLE) is a genetically predisposed, female-predominant
disease, characterized by multiple organ damage, that in its most severe forms can be life …
disease, characterized by multiple organ damage, that in its most severe forms can be life …
Neutrophil extracellular trap: A key player in the pathogenesis of autoimmune diseases
Numerous studies suggest that neutrophils might have a crucial role in the pathogenesis of
systemic autoimmune diseases through neutrophil extracellular trap (NET) formation …
systemic autoimmune diseases through neutrophil extracellular trap (NET) formation …
[HTML][HTML] NETs decorated with bioactive IL-33 infiltrate inflamed tissues and induce IFN-α production in patients with SLE
S Georgakis, K Gkirtzimanaki, G Papadaki… - JCI insight, 2021 - ncbi.nlm.nih.gov
IL-33, a nuclear alarmin released during cell death, exerts context-specific effects on
adaptive and innate immune cells, eliciting potent inflammatory responses. We screened …
adaptive and innate immune cells, eliciting potent inflammatory responses. We screened …
Neutrophil extracellular traps in autoimmunity and allergy: immune complexes at work
V Granger, M Peyneau, S Chollet-Martin… - Frontiers in …, 2019 - frontiersin.org
Neutrophil extracellular traps (NETs) have been initially described as main actors in host
defense owing to their ability to immobilize and sometimes kill microorganisms. Subsequent …
defense owing to their ability to immobilize and sometimes kill microorganisms. Subsequent …
Multi-omics links IL-6 trans-signalling with neutrophil extracellular trap formation and Haemophilus infection in COPD
Background: Interleukin (IL)-6 trans-signalling (IL-6TS) is emerging as a pathogenic
mechanism in chronic respiratory diseases; however, the drivers of IL-6TS in the airways …
mechanism in chronic respiratory diseases; however, the drivers of IL-6TS in the airways …