Human endogenous retroviruses (HERVs) are abundant sequences that persist within the
human genome as remnants of ancient retroviral infections. These sequences became fixed …

Liquid–liquid phase separation (LLPS) is a novel principle for explaining the precise spatial
and temporal regulation in living cells. LLPS compartmentalizes proteins and nucleic acids …

Diffuse midline glioma-H3K27M mutant (DMG) and glioblastoma (GBM) are the most lethal
brain tumors that primarily occur in pediatric and adult patients, respectively. Both tumors …

Recent advances in neoantigen research have accelerated the development and regulatory
approval of tumor immunotherapies, including cancer vaccines, adoptive cell therapy and …

The nucleus is highly organized, such that factors involved in the transcription and
processing of distinct classes of RNA are confined within specific nuclear bodies,. One …

Malignant transformation is characterized by dysregulation of diverse cellular processes that
have been the subject of detailed genetic, biochemical, and structural studies, but only …

This comprehensive Review delves into the chemical principles governing RNA-mediated
crowding events, commonly referred to as granules or biological condensates. We explore …

Abstract Cyclin D1 (CCND1), a crucial mediator of cell cycle progression, possesses many
mutation types with different mutation frequencies in human cancers. The G870A mutation is …

Neoantigens play a pivotal role in the field of tumour therapy, encompassing the stimulation
of anti-tumour immune response and the enhancement of tumour targeting capability …

Cancer vaccines hold considerable promise for the immunotherapy of solid tumors.
Nanomedicine offers several strategies for enhancing vaccine effectiveness. In particular …