Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P), two of the best-studied
lysophospholipids, are known to influence diverse biological events, including organismal …

Lysophosphatidic acid (LPA) is a simple phospholipid consisting of a phosphate group,
glycerol moiety, and only one hydrocarbon chain. Despite its simple chemical structure, LPA …

Synaptic communication is a dynamic process that is key to the regulation of neuronal
excitability and information processing in the brain. To date, however, the molecular signals …

Glutamate is the principal excitatory neurotransmitter in the central nervous system and its
actions are related to the behavioral effects of psychostimulant drugs. In the last two …

Experiments in rodents revealed neuropeptide S (NPS) to constitute a potential novel
treatment option for anxiety diseases such as panic and post-traumatic stress disorder …

Cocaine addiction disorder is notably aggravated by concomitant cognitive and emotional
pathology that impedes recovery. We studied whether a persistent cognitive/emotional …

Adverse early-life conditions induce persistent disturbances that give rise to negative
emotional states. Therefore, early life stress confers increased vulnerability to substance use …

To test the hypothesis that drugs of abuse and their conditioned stimuli (CSs) enhance
memory consolidation, the effects of post-training exposure to cocaine and nicotine were …

Erasing memories of cocaine–stimuli associations might have important clinical implications
for addiction therapy. Stimulating hippocampal plasticity by enhancing adult hippocampal …

Lysophosphatidic acid (LPA) has major roles as a bioactive signaling molecule, with
multiple physiological and pathological roles being described in almost every major organ …