Stress is an inevitable part of life. Chronic stress on account of reasons like adversity,
depression, anxiety, or loneliness/social isolation can endanger human health. Recent …

Stress is recognized as an important issue in basic and clinical neuroscience research,
based upon the founding historical studies by Walter Canon and Hans Selye in the past …

Major depressive disorder (MDD) is a prevalent psychiatric disease that involves
malfunctions of different cell types in the brain. Accumulating studies started to reveal that …

Crosstalk between inflammatory pathways and neurocircuits in the brain can lead to
behavioural responses, such as avoidance and alarm, that are likely to have provided early …

There is significant interest in understanding inflammatory responses within the brain and
spinal cord. Inflammatory responses that are centralized within the brain and spinal cord are …

Myriad clinical findings provide links between chronic stressors, inflammation, and mood
disorders. Furthermore, traumatic or chronic exposure to psychological stressors may …

Rationale Psychosocial stressors are a well-documented risk factor for mental illness.
Neuroinflammation, in particular elevated microglial activity, has been proposed to mediate …

Despite decades of intensive research, the biological mechanisms that causally underlie
depression are still unclear, and therefore the development of novel effective antidepressant …

Data from clinical and preclinical studies indicate that immune dysregulation, specifically of
inflammatory processes, is associated with symptoms of major depressive disorder (MDD) …

This review aims to synthesise a large pre-clinical and clinical literature related to a
hypothesised role of the locus coeruleus norepinephrine system in responses to acute and …