Elucidating the prefrontal cortical microcircuit has been challenging, given its role in multiple
complex behaviors, including working memory, cognitive flexibility, attention, social …

In the present article the putative role of environmental factors in schizophrenia is reviewed
and synthesized. Accumulating evidence from recent studies suggests that environmental …

Cortical GABAergic dysfunction may underlie the pathophysiology of psychiatric disorders,
including schizophrenia. Here, we characterized a mouse strain in which the essential NR1 …

Psychiatric disorders are complex multifactorial illnesses involving chronic alterations in
neural circuit structure and function as well as likely abnormalities in glial cells. While …

Hypofunction of N-methyl-d-aspartic acid-type glutamate receptors (NMDAR) induced by the
systemic administration of NMDAR antagonists is well known to cause schizophrenia-like …

There are numerous examples in psychology and other disciplines of the enduring effects of
early experience on neural function. In this article, we review the emerging evidence for …

Synchronization of neuronal activity in the neocortex may underlie the coordination of neural
representations and thus is critical for optimal cognitive function. Because cognitive deficits …

This review presents a brief overview of the γ-aminobutyric acid (GABA) system in the
develo** and mature central nervous system (CNS) and its potential connections to …

We have used a translational convergent functional genomics (CFG) approach to identify
and prioritize genes involved in schizophrenia, by gene-level integration of genome-wide …

In subjects with schizophrenia, impairments in working memory are associated with
dysfunction of the dorsolateral prefrontal cortex (DLPFC). This dysfunction appears to be …