Autophagy is an intracellular degradation pathway that recycles subcellular components to
maintain metabolic homeostasis. NAD is an essential metabolite that participates in energy …

The combination of genetics and genomics in Parkinson´ s disease has recently begun to
unveil molecular mechanisms possibly underlying disease onset and progression. In …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Our latest publication on the inhibition of Alzheimer disease (AD) through mitophagy
consolidates the 'defective mitophagy hypothesis of AD etiology'. Dementia (majorly AD) …

NADPH oxidase-derived reactive oxygen species (ROS) have been reported to activate
NLRP3 inflammasomes resulting in podocyte and glomerular injury during …

Signaling via pattern recognition receptors (PRRs) expressed on professional antigen
presenting cells, such as dendritic cells (DCs), is crucial to the fate of engulfed microbes …

ABSTRACT CD38 is a cell surface receptor capable of generating calcium-mobilizing
second messengers. It has been implicated in host defense and cancer biology, but …

Nicotinamide adenine dinucleotide (NAD+) is an important natural molecule involved in
fundamental biological processes, including the TCA cycle, OXPHOS, β-oxidation, and is a …

Lysosomal acid ceramidase (Ac) has been shown to be critical for ceramide hydrolysis and
regulation of lysosome function and cellular homeostasis. In the present study, we …