Coming of age: ten years of next-generation sequencing technologies
Since the completion of the human genome project in 2003, extraordinary progress has
been made in genome sequencing technologies, which has led to a decreased cost per …
been made in genome sequencing technologies, which has led to a decreased cost per …
Gene-expression signatures in breast cancer
This review discusses the results of DNA microarray signatures in breast cancer. These
signatures have been useful in the classification of breast cancers, and they have an …
signatures have been useful in the classification of breast cancers, and they have an …
Adjusting batch effects in microarray expression data using empirical Bayes methods
Non-biological experimental variation or “batch effects" are commonly observed across
multiple batches of microarray experiments, often rendering the task of combining data from …
multiple batches of microarray experiments, often rendering the task of combining data from …
Oncomine 3.0: genes, pathways, and networks in a collection of 18,000 cancer gene expression profiles
DNA microarrays have been widely applied to cancer transcriptome analysis; however, the
majority of such data are not easily accessible or comparable. Furthermore, several …
majority of such data are not easily accessible or comparable. Furthermore, several …
Oncogenic pathway signatures in human cancers as a guide to targeted therapies
The development of an oncogenic state is a complex process involving the accumulation of
multiple independent mutations that lead to deregulation of cell signalling pathways central …
multiple independent mutations that lead to deregulation of cell signalling pathways central …
Machine learning meta-analysis of large metagenomic datasets: tools and biological insights
Shotgun metagenomic analysis of the human associated microbiome provides a rich set of
microbial features for prediction and biomarker discovery in the context of human diseases …
microbial features for prediction and biomarker discovery in the context of human diseases …
Multi-cohort analysis of colorectal cancer metagenome identified altered bacteria across populations and universal bacterial markers
Background Alterations of gut microbiota are associated with colorectal cancer (CRC) in
different populations and several bacterial species were found to contribute to the …
different populations and several bacterial species were found to contribute to the …
METTL14-mediated N6-methyladenosine modification of SOX4 mRNA inhibits tumor metastasis in colorectal cancer
X Chen, MU Xu, X Xu, K Zeng, X Liu, B Pan, C Li… - Molecular cancer, 2020 - Springer
Background Colorectal cancer (CRC) is one of the leading causes of tumor-related death
worldwide, and its main cause of death is distant metastasis. Methyltransferase-like 14 …
worldwide, and its main cause of death is distant metastasis. Methyltransferase-like 14 …
Population structure discovery in meta-analyzed microbial communities and inflammatory bowel disease using MMUPHin
Microbiome studies of inflammatory bowel diseases (IBD) have achieved a scale for meta-
analysis of dysbioses among populations. To enable microbial community meta-analyses …
analysis of dysbioses among populations. To enable microbial community meta-analyses …
The cell cycle and cancer
GH Williams, K Stoeber - The Journal of pathology, 2012 - Wiley Online Library
Deregulation of the cell cycle underlies the aberrant cell proliferation that characterizes
cancer and loss of cell cycle checkpoint control promotes genetic instability. During the past …
cancer and loss of cell cycle checkpoint control promotes genetic instability. During the past …