Age-related macular degeneration (AMD) and glaucoma are degenerative conditions of the
retina and a significant cause of irreversible blindness in developed countries. Alzheimer's …

The homeostasis of iron is of fundamental importance in the central nervous system (CNS)
to ensure biological processes such as oxygen transport, mitochondrial respiration or myelin …

Iron is essential for cell survival and function. It is a transition metal, that could change its
oxidation state from Fe2+ to Fe3+ involving an electron transfer, the key of vital functions but …

The prion protein (PrPC), a mainly neuronal protein, is known to modulate glucose
homeostasis in mouse models. We explored the underlying mechanism in mouse models …

Secretory proteostasis integrates protein synthesis, processing, folding and trafficking
pathways that are essential for efficient cellular secretion. For the retinal pigment epithelium …

The cellular prion protein (PrPC) converts to alternatively folded pathogenic conformations
(PrPSc) in prion infections and binds neurotoxic oligomers formed by amyloid-β α-synuclein …

Endothelial-to-mesenchyme-like transition (Endo-MT) of trabecular meshwork (TM) cells is
known to be associated with primary open angle glaucoma (POAG). Here, we investigated …

Highly abundant in neurons, the cellular prion protein (PrPC) is an obligatory precursor to
the disease‐associated misfolded isoform denoted PrPSc that accumulates in the rare …

In this report, we evaluated the role of iron in sodium iodate (NaIO3)-induced model of age-
related macular degeneration (AMD) in ARPE-19 cells in-vitro, and mouse models in-vivo …

In the early stages of Alzheimer–Perusini's disease (AD), individuals often experience vision-
related issues such as color vision impairment, reduced contrast sensitivity, and visual acuity …