DNA in bacterial chromosomes is organized into higher‐order structures by DNA‐binding
proteins called nucleoid‐associated proteins (NAPs) or bacterial chromatin proteins (BCPs) …

Escherichia coli has been a vital model organism for studying chromosomal structure,
thanks, in part, to its small and circular genome (4.6 million base pairs) and well …

Mitochondrial activity directs neuronal differentiation dynamics during brain development. In
this context, the long-established metabolic coupling of mitochondria and the eukaryotic host …

The DNA double helix provides a simple and elegant way to store and copy genetic
information. However, the processes requiring the DNA helix strands separation, such as …

DNA gyrase is a type II topoisomerase with the unique capacity to introduce negative
supercoiling in DNA. In bacteria, DNA gyrase has an essential role in the homeostatic …

Chlamydia trachomatis is an obligate intracellular bacterium that is responsible for the most
prevalent bacterial sexually transmitted infection. Changes in DNA topology in this pathogen …

Microbial diseases including viral infection are big issues globally. Effective medicinal
discovery for them is the need for the day. In this study, we report pyrazole‐biphenyl …

Cold environments are more frequent than people think. They include deep oceans, cold
lakes, snow, permafrost, sea ice, glaciers, cold soils, cold deserts, caves, areas at elevations …

ABSTRACT DNA supercoiling acts as a global transcriptional regulator that contributes to
the rapid transcriptional response of bacteria to many environmental changes. Although a …

The efficiency and accuracy of CRISPR-Cas9 targeting varies considerably across genomic
targets and remains a persistent issue for using this system in cells. Studies have shown that …