Proteins are nature's primary building blocks for the construction of sophisticated molecular
machines and dynamic materials, ranging from protein complexes such as photosystem II …

Hierarchical materials that exhibit order over multiple length scales are ubiquitous in nature.
Because hierarchy gives rise to unique properties and functions, many have sought …

Nature endows life with a wide variety of sophisticated, synergistic, and highly functional
protein assemblies. Following Nature's inspiration to assemble protein building blocks into …

The bacterial type VI secretion system (T6SS) is an organelle that is structurally and
mechanistically analogous to an intracellular membrane-attached contractile phage tail …

Supramolecular protein assemblies are an emerging area within the chemical sciences,
which combine the topological structures of the field of supramolecular chemistry and the …

We describe a general computational method for designing proteins that self-assemble to a
desired symmetric architecture. Protein building blocks are docked together symmetrically to …

Type VI secretion systems are bacterial virulence-associated nanomachines composed of
proteins that are evolutionarily related to components of bacteriophage tails. Here we show …

Proteins, as the elemental basis of living organisms, mostly execute their biological tasks in
the form of supramolecular self-assemblies with subtle architectures, dynamic interactions …

Peptidoglycan is the major structural constituent of the bacterial cell wall, forming a
meshwork outside the cytoplasmic membrane that maintains cell shape and prevents lysis …

The functional spectrum of a secretion system is defined by its substrates. Here we analyzed
the secretomes of Pseudomonas aeruginosa mutants altered in regulation of the Hcp …