The immunologic role of IL-17 in psoriasis and psoriatic arthritis pathogenesis
A Blauvelt, A Chiricozzi - Clinical reviews in allergy & immunology, 2018 - Springer
Psoriasis is a chronic, immune-mediated, inflammatory disease that is pathogenically driven
by proinflammatory cytokines. This article reviews the immunologic role of interleukin (IL)-17 …
by proinflammatory cytokines. This article reviews the immunologic role of interleukin (IL)-17 …
Discovery of the IL-23/IL-17 signaling pathway and the treatment of psoriasis
Psoriasis vulgaris is a common, heterogeneous, chronic inflammatory skin disease
characterized by thickened, red, scaly plaques and systemic inflammation. Psoriasis is also …
characterized by thickened, red, scaly plaques and systemic inflammation. Psoriasis is also …
Interleukin-23-independent IL-17 production regulates intestinal epithelial permeability
Summary Whether interleukin-17A (IL-17A) has pathogenic and/or protective roles in the gut
mucosa is controversial and few studies have analyzed specific cell populations for …
mucosa is controversial and few studies have analyzed specific cell populations for …
The intestine harbors functionally distinct homeostatic tissue-resident and inflammatory Th17 cells
Summary T helper 17 (Th17) cells are pathogenic in many inflammatory diseases, but also
support the integrity of the intestinal barrier in a non-inflammatory manner. It is unclear what …
support the integrity of the intestinal barrier in a non-inflammatory manner. It is unclear what …
Immunopathogenesis of inflammatory bowel disease and mechanisms of biological therapies
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal
tract with a multifactorial pathophysiology. Full comprehension of IBD pathology is still out of …
tract with a multifactorial pathophysiology. Full comprehension of IBD pathology is still out of …
The role of interleukin-17 in tumor development and progression
IL-17, a potent proinflammatory cytokine, has been shown to intimately contribute to the
formation, growth, and metastasis of a wide range of malignancies. Recent studies implicate …
formation, growth, and metastasis of a wide range of malignancies. Recent studies implicate …
The cytokine IL-17A limits Th17 pathogenicity via a negative feedback loop driven by autocrine induction of IL-24
Dysregulated Th17 cell responses underlie multiple inflammatory and autoimmune
diseases, including autoimmune uveitis and its animal model, EAU. However, clinical trials …
diseases, including autoimmune uveitis and its animal model, EAU. However, clinical trials …
CD5L/AIM regulates lipid biosynthesis and restrains Th17 cell pathogenicity
Th17 cells play a critical role in host defense against extracellular pathogens and tissue
homeostasis but can induce autoimmunity. The mechanisms implicated in balancing" …
homeostasis but can induce autoimmunity. The mechanisms implicated in balancing" …
Anti-interleukin-17A monoclonal antibody secukinumab in treatment of ankylosing spondylitis: a randomised, double-blind, placebo-controlled trial
Background Ankylosing spondylitis is a chronic immune-mediated inflammatory disease
characterised by spinal inflammation, progressive spinal rigidity, and peripheral arthritis …
characterised by spinal inflammation, progressive spinal rigidity, and peripheral arthritis …
Targeting cytokines in inflammatory bowel disease
MF Neurath - Science translational medicine, 2022 - science.org
Targeting cytokines in inflammatory bowel disease (IBD) is a useful clinical approach.
Potential therapies for IBD include regulatory T cell transfer to restore cytokine balance …
Potential therapies for IBD include regulatory T cell transfer to restore cytokine balance …