Mitral valve disease—morphology and mechanisms
Mitral valve disease is a frequent cause of heart failure and death. Emerging evidence
indicates that the mitral valve is not a passive structure, but—even in adult life—remains …
indicates that the mitral valve is not a passive structure, but—even in adult life—remains …
Myocardial extracellular matrix: an ever-changing and diverse entity
M Rienks, AP Papageorgiou… - Circulation …, 2014 - Am Heart Assoc
The cardiac extracellular matrix (ECM) is a complex architectural network consisting of
structural and nonstructural proteins, creating strength and plasticity. The nonstructural …
structural and nonstructural proteins, creating strength and plasticity. The nonstructural …
Cardiac disease in patients with mucopolysaccharidosis: presentation, diagnosis and management
EA Braunlin, PR Harmatz, M Scarpa… - Journal of inherited …, 2011 - Springer
The mucopolysaccharidoses (MPSs) are inherited lysosomal storage disorders caused by
the absence of functional enzymes that contribute to the degradation of glycosaminoglycans …
the absence of functional enzymes that contribute to the degradation of glycosaminoglycans …
[HTML][HTML] Decellularized matrices for cardiovascular tissue engineering
F Moroni, T Mirabella - American journal of stem cells, 2014 - ncbi.nlm.nih.gov
Cardiovascular disease (CVD) is one of the leading causes of death in the Western world.
The replacement of damaged vessels and valves has been practiced since the 1950's …
The replacement of damaged vessels and valves has been practiced since the 1950's …
Biology and biomechanics of the heart valve extracellular matrix
KM Kodigepalli, K Thatcher, T West… - Journal of …, 2020 - mdpi.com
Heart valves are dynamic structures that, in the average human, open and close over
100,000 times per day, and 3× 109 times per lifetime to maintain unidirectional blood flow …
100,000 times per day, and 3× 109 times per lifetime to maintain unidirectional blood flow …
Matters of the heart: cellular sex differences
Nearly all cardiovascular diseases show sexual dimorphisms in prevalence, presentation,
and outcomes. Until recently, most clinical trials were carried out in males, and many animal …
and outcomes. Until recently, most clinical trials were carried out in males, and many animal …
Characterization of degenerative mitral valve disease: differences between fibroelastic deficiency and Barlow's disease
AL van Wijngaarden, BPT Kruithof, T Vinella… - Journal of …, 2021 - mdpi.com
Degenerative mitral valve disease causing mitral valve prolapse is the most common cause
of primary mitral regurgitation, with two distinct phenotypes generally recognized with some …
of primary mitral regurgitation, with two distinct phenotypes generally recognized with some …
Modulation of transforming growth factor-β signaling and extracellular matrix production in myxomatous mitral valves by angiotensin II receptor blockers
Background—Little is known about the pathophysiology of myxomatous degeneration of the
mitral valve, the pathological hallmark of mitral valve prolapse, associated with symptomatic …
mitral valve, the pathological hallmark of mitral valve prolapse, associated with symptomatic …
Identification of 2 loci associated with development of myxomatous mitral valve disease in Cavalier King Charles Spaniels
Myxomatous mitral valve disease (MMVD) is the most common heart disease in dogs. It is
characterized by chronic progressive degenerative lesions of the mitral valve. The valve …
characterized by chronic progressive degenerative lesions of the mitral valve. The valve …
Heart valve development, maintenance, and disease: the role of endothelial cells
Heart valves are dynamic structures that open and close during the cardiac cycle to maintain
unidirectional blood flow throughout life. Insufficient valve function, commonly due to …
unidirectional blood flow throughout life. Insufficient valve function, commonly due to …