TRPV3 Ion Channel: from gene to Pharmacology
AP Kalinovskii, LL Utkina, YV Korolkova… - International Journal of …, 2023 - mdpi.com
Transient receptor potential vanilloid subtype 3 (TRPV3) is an ion channel with a sensory
function that is most abundantly expressed in keratinocytes and peripheral neurons. TRPV3 …
function that is most abundantly expressed in keratinocytes and peripheral neurons. TRPV3 …
Transient receptor potential (TRP) channels in pain, neuropsychiatric disorders, and epilepsy
F Yang, A Sivils, V Cegielski, S Singh… - International journal of …, 2023 - mdpi.com
Pharmacomodulation of membrane channels is an essential topic in the study of
physiological conditions and disease status. Transient receptor potential (TRP) channels are …
physiological conditions and disease status. Transient receptor potential (TRP) channels are …
Human TRPV1 structure and inhibition by the analgesic SB-366791
Pain therapy has remained conceptually stagnant since the opioid crisis, which highlighted
the dangers of treating pain with opioids. An alternative addiction-free strategy to …
the dangers of treating pain with opioids. An alternative addiction-free strategy to …
A pentameric TRPV3 channel with a dilated pore
Transient receptor potential (TRP) channels are a large, eukaryotic ion channel superfamily
that control diverse physiological functions, and therefore are attractive drug targets,,,–. More …
that control diverse physiological functions, and therefore are attractive drug targets,,,–. More …
Structural mechanisms of TRPM7 activation and inhibition
The transient receptor potential channel TRPM7 is a master regulator of the organismal
balance of divalent cations that plays an essential role in embryonic development, immune …
balance of divalent cations that plays an essential role in embryonic development, immune …
Structure of human TRPV4 in complex with GTPase RhoA
Transient receptor potential (TRP) channel TRPV4 is a polymodal cellular sensor that
responds to moderate heat, cell swelling, shear stress, and small-molecule ligands. It is …
responds to moderate heat, cell swelling, shear stress, and small-molecule ligands. It is …
Molecular pathway and structural mechanism of human oncochannel TRPV6 inhibition by the phytocannabinoid tetrahydrocannabivarin
The calcium-selective oncochannel TRPV6 is an important driver of cell proliferation in
human cancers. Despite increasing interest of pharmacological research in develo** …
human cancers. Despite increasing interest of pharmacological research in develo** …
Structural mechanism of human oncochannel TRPV6 inhibition by the natural phytoestrogen genistein
Calcium-selective oncochannel TRPV6 is the major driver of cell proliferation in human
cancers. While significant effort has been invested in the development of synthetic TRPV6 …
cancers. While significant effort has been invested in the development of synthetic TRPV6 …
Structural basis of TRPV1 inhibition by SAF312 and cholesterol
Abstract Transient Receptor Potential Vanilloid 1 (TRPV1) plays a central role in pain
sensation and is thus an attractive pharmacological drug target. SAF312 is a potent …
sensation and is thus an attractive pharmacological drug target. SAF312 is a potent …
TRPV3 activation by different agonists accompanied by lipid dissociation from the vanilloid site
TRPV3 represents both temperature-and ligand-activated transient receptor potential (TRP)
channel. Physiologically relevant opening of TRPV3 channels by heat has been captured …
channel. Physiologically relevant opening of TRPV3 channels by heat has been captured …